JANÍKOVÁ, Andrea, Andrea MARECKOVA, A. BAUMEISTEROVA, Marta KREJČÍ, Jana ŠUPÍKOVÁ, David ŠÁLEK, Ondřej HORKÝ, Boris TICHÝ, Ivo HANKE, Šárka POSPÍŠILOVÁ, Mojmír MOULIS and Jiří MAYER. Transmission of t(11;14)-positive cells by allogeneic stem cell transplant: 10-year journey to mantle cell lymphoma. LEUKEMIA & LYMPHOMA, London: INFORMA HEALTHCARE, 2014, vol. 55, No 8, p. 1935-1938. ISSN 1042-8194. doi:10.3109/10428194.2013.858150.
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Basic information
Original name Transmission of t(11;14)-positive cells by allogeneic stem cell transplant: 10-year journey to mantle cell lymphoma
Authors JANÍKOVÁ, Andrea (203 Czech Republic, guarantor, belonging to the institution), Andrea MARECKOVA (203 Czech Republic), A. BAUMEISTEROVA (203 Czech Republic), Marta KREJČÍ (203 Czech Republic, belonging to the institution), Jana ŠUPÍKOVÁ (203 Czech Republic, belonging to the institution), David ŠÁLEK (203 Czech Republic), Ondřej HORKÝ (203 Czech Republic), Boris TICHÝ (203 Czech Republic, belonging to the institution), Ivo HANKE (203 Czech Republic, belonging to the institution), Šárka POSPÍŠILOVÁ (203 Czech Republic, belonging to the institution), Mojmír MOULIS (203 Czech Republic, belonging to the institution) and Jiří MAYER (203 Czech Republic, belonging to the institution).
Edition LEUKEMIA & LYMPHOMA, London, INFORMA HEALTHCARE, 2014, 1042-8194.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.891
RIV identification code RIV/00216224:14110/14:00074943
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.3109/10428194.2013.858150
UT WoS 000340224100041
Keywords in English BONE-MARROW-TRANSPLANTATION; POLYMERASE-CHAIN-REACTION; CLONAL IMMUNOGLOBULIN; RELAPSE; GENE
Tags EL OK, podil
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 16/10/2014 15:24.
Abstract
Mantle cell lymphoma (MCL) is considered, with some exceptions, to be one of the most aggressive lymphomas, with relatively short median survival [1]. Th e biological hallmark of MCL is t(11;14)(q13;q32) resulting in cyclin D1 overexpression, which is not usually expressed in normal B cells [2]. Although the initial oncogenic translocation is acquired at the pre-B stage during the V(D)J recombination in the bone marrow [3], MCL is composed of mature B cells that grow in the mantle zone of lymphatic follicles and express the corresponding phenotype. To date, the oncogenic steps from the early event to the development of MCL have not been well documented. Rare cases of donor-derived malignancies can provide better insights into the biology and growth of different tumors under real conditions.
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