SHAH, Ravi, Etienne GAYAT, James L. JANUZZI, Naoki SATO, Alain COHEN-SOLAL, Salvatore DISOMMA, Enrique FAIRMAN, Veli-Pekka HARJOLA, Shiro ISHIHARA, Johan LASSUS, Aldo MAGGIONI, Marco METRA, Christian MUELLER, Thomas MUELLER, Jiří PAŘENICA, Domingo PASCUAL-FIGAL, Frank PEACOCK, Jindřich ŠPINAR, Roland van KIMMENADE a Alexandre MEBAZAA. Body Mass Index and Mortality in Acutely Decompensated Heart Failure Across the World. Journal of The American College of Cardiology. NEW YORK: Elsevier Science, roč. 63, č. 8, s. 778-785. ISSN 0735-1097. doi:10.1016/j.jacc.2013.09.072. 2014.
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Základní údaje
Originální název Body Mass Index and Mortality in Acutely Decompensated Heart Failure Across the World
Autoři SHAH, Ravi (840 Spojené státy), Etienne GAYAT (250 Francie), James L. JANUZZI (840 Spojené státy), Naoki SATO (392 Japonsko), Alain COHEN-SOLAL (250 Francie), Salvatore DISOMMA (380 Itálie), Enrique FAIRMAN (32 Argentina), Veli-Pekka HARJOLA (246 Finsko), Shiro ISHIHARA (392 Japonsko), Johan LASSUS (246 Finsko), Aldo MAGGIONI (380 Itálie), Marco METRA (380 Itálie), Christian MUELLER (756 Švýcarsko), Thomas MUELLER (40 Rakousko), Jiří PAŘENICA (203 Česká republika, domácí), Domingo PASCUAL-FIGAL (724 Španělsko), Frank PEACOCK (840 Spojené státy), Jindřich ŠPINAR (203 Česká republika, garant, domácí), Roland van KIMMENADE (528 Nizozemské království) a Alexandre MEBAZAA (250 Francie).
Vydání Journal of The American College of Cardiology, NEW YORK, Elsevier Science, 2014, 0735-1097.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30201 Cardiac and Cardiovascular systems
Stát vydavatele Spojené státy
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 16.503
Kód RIV RIV/00216224:14110/14:00074969
Organizační jednotka Lékařská fakulta
Doi http://dx.doi.org/10.1016/j.jacc.2013.09.072
UT WoS 000331720900005
Klíčová slova anglicky heart failure; obesity; obesity paradox
Štítky EL OK
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Ing. Mgr. Věra Pospíšilíková, učo 9005. Změněno: 15. 4. 2014 12:00.
Anotace
Objective To define the relationship between body mass index (BMI) and mortality in heart failure (HF) across the world and identify specific groups in whom BMI may differentially mediate risk. Background Obesity is associated with incident heart failure (HF), but is paradoxically associated with better prognosis during chronic HF. Methods We studied 6,142 patients with acute decompensated HF from 12 prospective observational cohorts followed across 4 continents. Primary outcome was all-cause mortality. Cox proportional hazards models and net reclassification index (NRI) described associations of BMI with all-cause mortality. Results “Normal” weight patients (BMI 18.5-25 kg/m2) were older with more advanced HF and lower cardiometabolic risk. Despite worldwide heterogeneity in clinical features across obesity categories, a higher BMI remained associated with decreased 30-day and 1-year mortality (11% decrease at 30 days; 9% decrease at 1 year per 5 kg/m2; P<0.05), after adjustment for clinical risk. BMI obtained at index admission provided effective 1-year risk reclassification beyond current markers of clinical risk (NRI 0.119, P <.001). Notably, the “protective” association of BMI with mortality was confined to those with older age (>75; HR=0.82, P=0.006), decreased cardiac function (ejection fraction < 50%; HR=0.85, P<.001), non-diabetics (HR=0.86, P<.001), and de novo HF (HR=0.89, P=0.004). Conclusions A lower BMI is associated with age, disease severity, and a higher risk of death in ADHF. The “obesity paradox” is confined to older individuals, decreased cardiac function, less cardiometabolic illness, and recent onset HF, suggesting that aging, HF severity/chronicity, and metabolism may explain the obesity paradox.
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