Leading compounds for the validation of animal models of
psychopathology

J 2013

Leading compounds for the validation of animal models of psychopathology

MICALE, Vincenzo, Jana KUČEROVÁ and Alexandra ŠULCOVÁ

Basic information

Original name

Leading compounds for the validation of animal models of psychopathology

Authors

MICALE, Vincenzo (380 Italy, belonging to the institution), Jana KUČEROVÁ (203 Czech Republic, belonging to the institution) and Alexandra ŠULCOVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

CELL AND TISSUE RESEARCH, Heidelberg, Springer Verlag, 2013, 0302-766X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.333

RIV identification code

RIV/00216224:14740/13:00071642

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1007/s00441-013-1692-9

UT WoS

000325103500025

Keywords in English

Depression; Schizophrenia; Animal models; Antipsychotics; Antidepressants

Abstract

V originále

Modelling of complex psychiatric disorders, e.g., depression and schizophrenia, in animals is a major challenge, since they are characterized by certain disturbances in functions that are absolutely unique to humans. Furthermore, we still have not identified the genetic and neurobiological mechanisms, nor do we know precisely the circuits in the brain that function abnormally in mood and psychotic disorders. Consequently, the pharmacological treatments used are mostly variations on a theme that was started more than 50 years ago. Thus, progress in novel drug development with improved therapeutic efficacy would benefit greatly from improved animal models. Here, we review the available animal models of depression and schizophrenia and focus on the way that they respond to various types of potential candidate molecules, such as novel antidepressant or antipsychotic drugs, as an index of predictive validity. We conclude that the generation of convincing and useful animal models of mental illnesses could be a bridge to success in drug discovery.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

Citovat

MICALE, Vincenzo, Jana KUČEROVÁ and Alexandra ŠULCOVÁ. Leading compounds for the validation of animal models of psychopathology. CELL AND TISSUE RESEARCH. Heidelberg: Springer Verlag, 2013, vol. 354, No 1, p. 309-330. ISSN 0302-766X. Available from: https://dx.doi.org/10.1007/s00441-013-1692-9.

@article{1162011,
   author = {Micale, Vincenzo and Kučerová, Jana and Šulcová, Alexandra},
   article_location = {Heidelberg},
   article_number = {1},
   doi = {http://dx.doi.org/10.1007/s00441-013-1692-9},
   keywords = {Depression; Schizophrenia; Animal models; Antipsychotics; Antidepressants},
   language = {eng},
   issn = {0302-766X},
   journal = {CELL AND TISSUE RESEARCH},
   title = {Leading compounds for the validation of animal models of psychopathology},
   url = {http://link.springer.com/article/10.1007%2Fs00441-013-1692-9},
   volume = {354},
   year = {2013}
}

TY  - JOUR
ID  - 1162011
AU  - Micale, Vincenzo - Kučerová, Jana - Šulcová, Alexandra
PY  - 2013
TI  - Leading compounds for the validation of animal models of psychopathology
JF  - CELL AND TISSUE RESEARCH
VL  - 354
IS  - 1
SP  - 309-330
EP  - 309-330
PB  - Springer Verlag
SN  - 0302766X
KW  - Depression
KW  - Schizophrenia
KW  - Animal models
KW  - Antipsychotics
KW  - Antidepressants
UR  - http://link.springer.com/article/10.1007%2Fs00441-013-1692-9
L2  - http://link.springer.com/article/10.1007%2Fs00441-013-1692-9
N2  - Modelling of complex psychiatric disorders, e.g., depression and schizophrenia, in animals is a major challenge, since they are characterized by certain disturbances in functions that are absolutely unique to humans. Furthermore, we still have not identified the genetic and neurobiological mechanisms, nor do we know precisely the circuits in the brain that function abnormally in mood and psychotic disorders. Consequently, the pharmacological treatments used are mostly variations on a theme that was started more than 50 years ago. Thus, progress in novel drug development with improved therapeutic efficacy would benefit greatly from improved animal models. Here, we review the available animal models of depression and schizophrenia and focus on the way that they respond to various types of potential candidate molecules, such as novel antidepressant or antipsychotic drugs, as an index of predictive validity. We conclude that the generation of convincing and useful animal models of mental illnesses could be a bridge to success in drug discovery.
ER  -

MICALE, Vincenzo, Jana KUČEROVÁ and Alexandra ŠULCOVÁ. Leading compounds for the validation of animal models of psychopathology. \textit{CELL AND TISSUE RESEARCH}. Heidelberg: Springer Verlag, 2013, vol.~354, No~1, p.~309-330. ISSN~0302-766X. Available from: https://dx.doi.org/10.1007/s00441-013-1692-9.

Detailed Information on Publication Record