MICA, L., C. KELLER, Jindřich VOMELA, O. TRENTZ, M. PLECKO and M.J. KEEL. The impact of body mass index and gender on the development of infectious complications in polytrauma patients. European Journal of Trauma and Emergency Surgery. Munich: Urban & Vogel, 2014, vol. 40, No 5, p. 573-579. ISSN 1863-9933. Available from: https://dx.doi.org/10.1007/s00068-013-0300-8.
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Basic information
Original name The impact of body mass index and gender on the development of infectious complications in polytrauma patients
Authors MICA, L. (756 Switzerland), C. KELLER (756 Switzerland), Jindřich VOMELA (203 Czech Republic, guarantor, belonging to the institution), O. TRENTZ (756 Switzerland), M. PLECKO (756 Switzerland) and M.J. KEEL (756 Switzerland).
Edition European Journal of Trauma and Emergency Surgery, Munich, Urban & Vogel, 2014, 1863-9933.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher Germany
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 0.346
RIV identification code RIV/00216224:14110/14:00074999
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1007/s00068-013-0300-8
UT WoS 000343916100010
Keywords in English body mass index; gender; polytrauma; infection; ISS
Tags EL OK
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 28/1/2015 14:30.
Abstract
Purpose The aim was to test the impact of body mass index (BMI) and gender on infectious complications after polytrauma. Methods: A total of 651 patients were included in this retrospective study, with an Injury Severity Score (ISS) >= 16 and age >= 16 years. The sample was subdivided into three groups: BMI <25 kg/m(2), BMI 25-30 kg/m(2), and BMI >30 kg/m(2), and a female and a male group. Infectious complications were observed for 31 days after admission. Data are given as mean +/- standard errors of the means. Analysis of variance, Kruskal-Wallis test, chi(2) tests, and Pearson's correlation were used for the analyses and the significance level was set at P < 0.05. Results: The overall infection rates were 31.0 % in the BMI < 25 kg/m(2) group, 29.0 % in the BMI 25-30 kg/m(2) group, and 24.5 % in the BMI > 30 kg/m(2) group (P = 0.519). The female patients developed significantly fewer infectious complications than the male patients (26.8 vs. 73.2 %; P < 0.001). The incidence of death was significantly decreased according to the BMI group (8.8 vs. 7.2 vs. 1.5 %; P < 0.0001) and the female population had a significantly lower mortality rate (4.1 vs. 13.4 %; P < 0.0001). Pearson's correlations between the Abbreviated Injury Scale (AIS) score and the corresponding infectious foci were not significant. Conclusion: Higher BMI seems to be protective against polytrauma-associated death but not polytrauma-associated infections, and female gender protects against both polytrauma-associated infections and death. Understanding gender-specific immunomodulation could improve the outcome of polytrauma patients.
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