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@article{1163395, author = {Mica, L. and Keller, C. and Vomela, Jindřich and Trentz, O. and Plecko, M. and Keel, M.J.}, article_location = {Munich}, article_number = {5}, doi = {http://dx.doi.org/10.1007/s00068-013-0300-8}, keywords = {body mass index; gender; polytrauma; infection; ISS}, language = {eng}, issn = {1863-9933}, journal = {European Journal of Trauma and Emergency Surgery}, title = {The impact of body mass index and gender on the development of infectious complications in polytrauma patients}, volume = {40}, year = {2014} }
TY - JOUR ID - 1163395 AU - Mica, L. - Keller, C. - Vomela, Jindřich - Trentz, O. - Plecko, M. - Keel, M.J. PY - 2014 TI - The impact of body mass index and gender on the development of infectious complications in polytrauma patients JF - European Journal of Trauma and Emergency Surgery VL - 40 IS - 5 SP - 573-579 EP - 573-579 PB - Urban & Vogel SN - 18639933 KW - body mass index KW - gender KW - polytrauma KW - infection KW - ISS N2 - Purpose The aim was to test the impact of body mass index (BMI) and gender on infectious complications after polytrauma. Methods: A total of 651 patients were included in this retrospective study, with an Injury Severity Score (ISS) >= 16 and age >= 16 years. The sample was subdivided into three groups: BMI <25 kg/m(2), BMI 25-30 kg/m(2), and BMI >30 kg/m(2), and a female and a male group. Infectious complications were observed for 31 days after admission. Data are given as mean +/- standard errors of the means. Analysis of variance, Kruskal-Wallis test, chi(2) tests, and Pearson's correlation were used for the analyses and the significance level was set at P < 0.05. Results: The overall infection rates were 31.0 % in the BMI < 25 kg/m(2) group, 29.0 % in the BMI 25-30 kg/m(2) group, and 24.5 % in the BMI > 30 kg/m(2) group (P = 0.519). The female patients developed significantly fewer infectious complications than the male patients (26.8 vs. 73.2 %; P < 0.001). The incidence of death was significantly decreased according to the BMI group (8.8 vs. 7.2 vs. 1.5 %; P < 0.0001) and the female population had a significantly lower mortality rate (4.1 vs. 13.4 %; P < 0.0001). Pearson's correlations between the Abbreviated Injury Scale (AIS) score and the corresponding infectious foci were not significant. Conclusion: Higher BMI seems to be protective against polytrauma-associated death but not polytrauma-associated infections, and female gender protects against both polytrauma-associated infections and death. Understanding gender-specific immunomodulation could improve the outcome of polytrauma patients. ER -
MICA, L., C. KELLER, Jindřich VOMELA, O. TRENTZ, M. PLECKO and M.J. KEEL. The impact of body mass index and gender on the development of infectious complications in polytrauma patients. \textit{European Journal of Trauma and Emergency Surgery}. Munich: Urban \&{} Vogel, 2014, vol.~40, No~5, p.~573-579. ISSN~1863-9933. Available from: https://dx.doi.org/10.1007/s00068-013-0300-8.
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