J 2014

The impact of body mass index and gender on the development of infectious complications in polytrauma patients

MICA, L., C. KELLER, Jindřich VOMELA, O. TRENTZ, M. PLECKO et. al.

Basic information

Original name

The impact of body mass index and gender on the development of infectious complications in polytrauma patients

Authors

MICA, L. (756 Switzerland), C. KELLER (756 Switzerland), Jindřich VOMELA (203 Czech Republic, guarantor, belonging to the institution), O. TRENTZ (756 Switzerland), M. PLECKO (756 Switzerland) and M.J. KEEL (756 Switzerland)

Edition

European Journal of Trauma and Emergency Surgery, Munich, Urban & Vogel, 2014, 1863-9933

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 0.346

RIV identification code

RIV/00216224:14110/14:00074999

Organization unit

Faculty of Medicine

DOI

UT WoS

000343916100010

Keywords in English

body mass index; gender; polytrauma; infection; ISS

Tags

Tags

International impact, Reviewed
Změněno: 28/1/2015 14:30, Soňa Böhmová

Abstract

V originále

Purpose The aim was to test the impact of body mass index (BMI) and gender on infectious complications after polytrauma. Methods: A total of 651 patients were included in this retrospective study, with an Injury Severity Score (ISS) >= 16 and age >= 16 years. The sample was subdivided into three groups: BMI <25 kg/m(2), BMI 25-30 kg/m(2), and BMI >30 kg/m(2), and a female and a male group. Infectious complications were observed for 31 days after admission. Data are given as mean +/- standard errors of the means. Analysis of variance, Kruskal-Wallis test, chi(2) tests, and Pearson's correlation were used for the analyses and the significance level was set at P < 0.05. Results: The overall infection rates were 31.0 % in the BMI < 25 kg/m(2) group, 29.0 % in the BMI 25-30 kg/m(2) group, and 24.5 % in the BMI > 30 kg/m(2) group (P = 0.519). The female patients developed significantly fewer infectious complications than the male patients (26.8 vs. 73.2 %; P < 0.001). The incidence of death was significantly decreased according to the BMI group (8.8 vs. 7.2 vs. 1.5 %; P < 0.0001) and the female population had a significantly lower mortality rate (4.1 vs. 13.4 %; P < 0.0001). Pearson's correlations between the Abbreviated Injury Scale (AIS) score and the corresponding infectious foci were not significant. Conclusion: Higher BMI seems to be protective against polytrauma-associated death but not polytrauma-associated infections, and female gender protects against both polytrauma-associated infections and death. Understanding gender-specific immunomodulation could improve the outcome of polytrauma patients.