| BEDNAŘÍK, Antonín, Pavel KUBA, Eugene MOSKOVETS, Iva TOMALOVÁ, Pavel KRÁSENSKÝ, Pavel HOUŠKA a Jan PREISLER. Rapid Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Imaging with Scanning Desorption Laser Beam. Analytical Chemistry. Washington: American Chemical Society, 2014, roč. 86, č. 2, s. 982-986. ISSN 0003-2700. Dostupné z: https://dx.doi.org/10.1021/ac402823n. |
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@article{1164080,
author = {Bednařík, Antonín and Kuba, Pavel and Moskovets, Eugene and Tomalová, Iva and Krásenský, Pavel and Houška, Pavel and Preisler, Jan},
article_location = {Washington},
article_number = {2},
doi = {http://dx.doi.org/10.1021/ac402823n},
keywords = {Mass spectrometry imaging; laser beam scanning; MALDI; TOF; high-throughput},
language = {eng},
issn = {0003-2700},
journal = {Analytical Chemistry},
title = {Rapid Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Imaging with Scanning Desorption Laser Beam},
url = {http://pubs.acs.org/doi/abs/10.1021/ac402823n},
volume = {86},
year = {2014}
}
TY - JOUR
ID - 1164080
AU - Bednařík, Antonín - Kuba, Pavel - Moskovets, Eugene - Tomalová, Iva - Krásenský, Pavel - Houška, Pavel - Preisler, Jan
PY - 2014
TI - Rapid Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Imaging with Scanning Desorption Laser Beam
JF - Analytical Chemistry
VL - 86
IS - 2
SP - 982-986
EP - 982-986
PB - American Chemical Society
SN - 00032700
KW - Mass spectrometry imaging
KW - laser beam scanning
KW - MALDI
KW - TOF
KW - high-throughput
UR - http://pubs.acs.org/doi/abs/10.1021/ac402823n
L2 - http://pubs.acs.org/doi/abs/10.1021/ac402823n
N2 - This work shows that a substantial increase in the throughput of the TOF MS-based tissue imaging can be achieved by incorporating a mirror providing high-speed precision scanning of the laser beam along the sample surface. Equipped with the scanning mirror, a laboratory-built axial MALDI TOF MS instrument utilizing a 4-kHz UV laser recorded a 100 x 100 pixel MS image in 11 min using 100 laser shots per pixel. This is almost an order of magnitude faster when compared to a modern commercial instrument equipped with 1-kHz laser.
ER -
BEDNAŘÍK, Antonín, Pavel KUBA, Eugene MOSKOVETS, Iva TOMALOVÁ, Pavel KRÁSENSKÝ, Pavel HOUŠKA a Jan PREISLER. Rapid Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Imaging with Scanning Desorption Laser Beam. \textit{Analytical Chemistry}. Washington: American Chemical Society, 2014, roč.~86, č.~2, s.~982-986. ISSN~0003-2700. Dostupné z: https://dx.doi.org/10.1021/ac402823n.
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