BEDNAŘÍK, Antonín, Pavel KUBA, Eugene MOSKOVETS, Iva TOMALOVÁ, Pavel KRÁSENSKÝ, Pavel HOUŠKA and Jan PREISLER. Rapid Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Imaging with Scanning Desorption Laser Beam. Analytical Chemistry. Washington: American Chemical Society, 2014, vol. 86, No 2, p. 982-986. ISSN 0003-2700. Available from: https://dx.doi.org/10.1021/ac402823n. |
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@article{1164080, author = {Bednařík, Antonín and Kuba, Pavel and Moskovets, Eugene and Tomalová, Iva and Krásenský, Pavel and Houška, Pavel and Preisler, Jan}, article_location = {Washington}, article_number = {2}, doi = {http://dx.doi.org/10.1021/ac402823n}, keywords = {Mass spectrometry imaging; laser beam scanning; MALDI; TOF; high-throughput}, language = {eng}, issn = {0003-2700}, journal = {Analytical Chemistry}, title = {Rapid Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Imaging with Scanning Desorption Laser Beam}, url = {http://pubs.acs.org/doi/abs/10.1021/ac402823n}, volume = {86}, year = {2014} }
TY - JOUR ID - 1164080 AU - Bednařík, Antonín - Kuba, Pavel - Moskovets, Eugene - Tomalová, Iva - Krásenský, Pavel - Houška, Pavel - Preisler, Jan PY - 2014 TI - Rapid Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Imaging with Scanning Desorption Laser Beam JF - Analytical Chemistry VL - 86 IS - 2 SP - 982-986 EP - 982-986 PB - American Chemical Society SN - 00032700 KW - Mass spectrometry imaging KW - laser beam scanning KW - MALDI KW - TOF KW - high-throughput UR - http://pubs.acs.org/doi/abs/10.1021/ac402823n L2 - http://pubs.acs.org/doi/abs/10.1021/ac402823n N2 - This work shows that a substantial increase in the throughput of the TOF MS-based tissue imaging can be achieved by incorporating a mirror providing high-speed precision scanning of the laser beam along the sample surface. Equipped with the scanning mirror, a laboratory-built axial MALDI TOF MS instrument utilizing a 4-kHz UV laser recorded a 100 x 100 pixel MS image in 11 min using 100 laser shots per pixel. This is almost an order of magnitude faster when compared to a modern commercial instrument equipped with 1-kHz laser. ER -
BEDNAŘÍK, Antonín, Pavel KUBA, Eugene MOSKOVETS, Iva TOMALOVÁ, Pavel KRÁSENSKÝ, Pavel HOUŠKA and Jan PREISLER. Rapid Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Imaging with Scanning Desorption Laser Beam. \textit{Analytical Chemistry}. Washington: American Chemical Society, 2014, vol.~86, No~2, p.~982-986. ISSN~0003-2700. Available from: https://dx.doi.org/10.1021/ac402823n.
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