Podrobný výpis o publikaci

HÝŽA, Martin, Jitka HÜTTLOVÁ, Miloš KEŘKOVSKÝ a Tomáš KAŠPÁREK. Psychosis effect on hippocampal reduction in schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry. Oxford: Pergamon-Elsevier Ltd., roč. 48, 3 Jan 2014, s. 186-192. ISSN 0278-5846. doi:10.1016/j.pnpbp.2013.10.008. 2014.

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Základní údaje
Originální název	Psychosis effect on hippocampal reduction in schizophrenia
Název česky	Efekt psychózy na redukci objemu hippokampů u schizofrenie
Autoři	HÝŽA, Martin (203 Česká republika, domácí), Jitka HÜTTLOVÁ (203 Česká republika, domácí), Miloš KEŘKOVSKÝ (203 Česká republika, domácí) a Tomáš KAŠPÁREK (203 Česká republika, garant, domácí).
Vydání	Progress in Neuro-Psychopharmacology and Biological Psychiatry, Oxford, Pergamon-Elsevier Ltd. 2014, 0278-5846.

Další údaje
Originální jazyk	angličtina
Typ výsledku	Článek v odborném periodiku
Obor	30000 3. Medical and Health Sciences
Stát vydavatele	Velká Británie a Severní Irsko
Utajení	není předmětem státního či obchodního tajemství
Impakt faktor	Impact factor: 3.689
Kód RIV	RIV/00216224:14110/14:00075026
Organizační jednotka	Lékařská fakulta
Doi	http://dx.doi.org/10.1016/j.pnpbp.2013.10.008
UT WoS	000328074200027
Klíčová slova česky	hipokampus; morfometrie; psychóza; schizofrenie; toxicita
Klíčová slova anglicky	hippocampus; morphometry; psychosis; schizophrenia; toxicity
Štítky	10 02 2014, EL OK
Příznaky	Mezinárodní význam, Recenzováno
Změnil	Změnila: Soňa Böhmová, učo 232884. Změněno: 4. 3. 2014 17:03.

Anotace
Introduction: In schizophrenia, disruption of the neurodevelopmental processes may lead to brain changes and subsequent clinical manifestations of the illness. Reports of the progressive nature of these morphological brain changes raise questions about their causes. The possible toxic effects of repeated stressful psychotic episodes may contribute to the disease progression. Objectives: To analyze the influence of illness duration and previous psychotic episodes on hippocampal gray matter volume (GMV) in schizophrenia. Methods: We performed an analysis of hippocampal GMV correlations with illness duration, number of previous psychotic episodes, and age in 24 schizophrenia patients and 24 matched healthy controls. Results: We found a cluster of GMV voxels in the left hippocampal tail that negatively correlated with the number of previous psychotic episodes, independent from the effect of age. On the other hand we found no effect of illness duration independent of age on the hippocampal GMV. Finally, we found a cluster of significant group-by-age interaction in the left hippocampal head. Conclusions: We found an additive adverse effect of psychotic episodes on hippocampal morphology in schizophrenia. Our findings support toxicity of psychosis concept, together with etiological heterogeneity of brain changes in schizophrenia.

Anotace

Introduction: In schizophrenia, disruption of the neurodevelopmental processes may lead to brain changes and subsequent clinical manifestations of the illness. Reports of the progressive nature of these morphological brain changes raise questions about their causes. The possible toxic effects of repeated stressful psychotic episodes may contribute to the disease progression. Objectives: To analyze the influence of illness duration and previous psychotic episodes on hippocampal gray matter volume (GMV) in schizophrenia. Methods: We performed an analysis of hippocampal GMV correlations with illness duration, number of previous psychotic episodes, and age in 24 schizophrenia patients and 24 matched healthy controls. Results: We found a cluster of GMV voxels in the left hippocampal tail that negatively correlated with the number of previous psychotic episodes, independent from the effect of age. On the other hand we found no effect of illness duration independent of age on the hippocampal GMV. Finally, we found a cluster of significant group-by-age interaction in the left hippocampal head. Conclusions: We found an additive adverse effect of psychotic episodes on hippocampal morphology in schizophrenia. Our findings support toxicity of psychosis concept, together with etiological heterogeneity of brain changes in schizophrenia.