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@article{1164082,
author = {Hýža, Martin and Hüttlová, Jitka and Keřkovský, Miloš and Kašpárek, Tomáš},
article_location = {Oxford},
article_number = {3 Jan 2014},
doi = {http://dx.doi.org/10.1016/j.pnpbp.2013.10.008},
keywords = {hippocampus; morphometry; psychosis; schizophrenia; toxicity},
language = {eng},
issn = {0278-5846},
journal = {Progress in Neuro-Psychopharmacology and Biological Psychiatry},
title = {Psychosis effect on hippocampal reduction in schizophrenia},
volume = {48},
year = {2014}
}
TY - JOUR
ID - 1164082
AU - Hýža, Martin - Hüttlová, Jitka - Keřkovský, Miloš - Kašpárek, Tomáš
PY - 2014
TI - Psychosis effect on hippocampal reduction in schizophrenia
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
VL - 48
IS - 3 Jan 2014
SP - 186-192
EP - 186-192
PB - Pergamon-Elsevier Ltd.
SN - 02785846
KW - hippocampus
KW - morphometry
KW - psychosis
KW - schizophrenia
KW - toxicity
N2 - Introduction: In schizophrenia, disruption of the neurodevelopmental processes may lead to brain changes and subsequent clinical manifestations of the illness. Reports of the progressive nature of these morphological brain changes raise questions about their causes. The possible toxic effects of repeated stressful psychotic episodes may contribute to the disease progression. Objectives: To analyze the influence of illness duration and previous psychotic episodes on hippocampal gray matter volume (GMV) in schizophrenia. Methods: We performed an analysis of hippocampal GMV correlations with illness duration, number of previous psychotic episodes, and age in 24 schizophrenia patients and 24 matched healthy controls. Results: We found a cluster of GMV voxels in the left hippocampal tail that negatively correlated with the number of previous psychotic episodes, independent from the effect of age. On the other hand we found no effect of illness duration independent of age on the hippocampal GMV. Finally, we found a cluster of significant group-by-age interaction in the left hippocampal head. Conclusions: We found an additive adverse effect of psychotic episodes on hippocampal morphology in schizophrenia. Our findings support toxicity of psychosis concept, together with etiological heterogeneity of brain changes in schizophrenia.
ER -
HÝŽA, Martin, Jitka HÜTTLOVÁ, Miloš KEŘKOVSKÝ and Tomáš KAŠPÁREK. Psychosis effect on hippocampal reduction in schizophrenia. Online. \textit{Progress in Neuro-Psychopharmacology and Biological Psychiatry}. Oxford: Pergamon-Elsevier Ltd., 2014, vol.~48, 3 Jan 2014, p.~186-192. ISSN~0278-5846. Available from: https://dx.doi.org/10.1016/j.pnpbp.2013.10.008. [citováno 2024-04-24]
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