HÝŽA, Martin, Jitka HÜTTLOVÁ, Miloš KEŘKOVSKÝ and Tomáš KAŠPÁREK. Psychosis effect on hippocampal reduction in schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry. Oxford: Pergamon-Elsevier Ltd., 2014, vol. 48, 3 Jan 2014, p. 186-192. ISSN 0278-5846. doi:10.1016/j.pnpbp.2013.10.008.
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Basic information
Original name Psychosis effect on hippocampal reduction in schizophrenia
Name in Czech Efekt psychózy na redukci objemu hippokampů u schizofrenie
Authors HÝŽA, Martin (203 Czech Republic, belonging to the institution), Jitka HÜTTLOVÁ (203 Czech Republic, belonging to the institution), Miloš KEŘKOVSKÝ (203 Czech Republic, belonging to the institution) and Tomáš KAŠPÁREK (203 Czech Republic, guarantor, belonging to the institution).
Edition Progress in Neuro-Psychopharmacology and Biological Psychiatry, Oxford, Pergamon-Elsevier Ltd. 2014, 0278-5846.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 3.689
RIV identification code RIV/00216224:14110/14:00075026
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.pnpbp.2013.10.008
UT WoS 000328074200027
Keywords (in Czech) hipokampus; morfometrie; psychóza; schizofrenie; toxicita
Keywords in English hippocampus; morphometry; psychosis; schizophrenia; toxicity
Tags 10 02 2014, EL OK
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 4/3/2014 17:03.
Introduction: In schizophrenia, disruption of the neurodevelopmental processes may lead to brain changes and subsequent clinical manifestations of the illness. Reports of the progressive nature of these morphological brain changes raise questions about their causes. The possible toxic effects of repeated stressful psychotic episodes may contribute to the disease progression. Objectives: To analyze the influence of illness duration and previous psychotic episodes on hippocampal gray matter volume (GMV) in schizophrenia. Methods: We performed an analysis of hippocampal GMV correlations with illness duration, number of previous psychotic episodes, and age in 24 schizophrenia patients and 24 matched healthy controls. Results: We found a cluster of GMV voxels in the left hippocampal tail that negatively correlated with the number of previous psychotic episodes, independent from the effect of age. On the other hand we found no effect of illness duration independent of age on the hippocampal GMV. Finally, we found a cluster of significant group-by-age interaction in the left hippocampal head. Conclusions: We found an additive adverse effect of psychotic episodes on hippocampal morphology in schizophrenia. Our findings support toxicity of psychosis concept, together with etiological heterogeneity of brain changes in schizophrenia.
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