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@article{1164098,
author = {Ševčíková, Romana and Lubal, Přemysl and Campello, Maria Paula Cabral and Santos, Isabel},
article_location = {Oxford},
article_number = {OCT 7 2013},
doi = {http://dx.doi.org/10.1016/j.poly.2013.06.052},
keywords = {Macrocyclic ligands; Cyclen derivatives; Thiol group; Copper/zinc complexes; Formation/dissociation kinetics; Rate constants; Radiopharmaceuticals},
language = {eng},
issn = {0277-5387},
journal = {Polyhedron},
title = {Kinetic study of formation/dissociation of Cu(II) and Zn(II) complexes of cyclen macrocyclic ligand with pendant thiol group},
url = {http://www.sciencedirect.com/science/article/pii/S0277538713005111#},
volume = {62},
year = {2013}
}
TY - JOUR
ID - 1164098
AU - Ševčíková, Romana - Lubal, Přemysl - Campello, Maria Paula Cabral - Santos, Isabel
PY - 2013
TI - Kinetic study of formation/dissociation of Cu(II) and Zn(II) complexes of cyclen macrocyclic ligand with pendant thiol group
JF - Polyhedron
VL - 62
IS - OCT 7 2013
SP - 268-273
EP - 268-273
PB - Pergamon-Elsevier Science
SN - 02775387
KW - Macrocyclic ligands
KW - Cyclen derivatives
KW - Thiol group
KW - Copper/zinc complexes
KW - Formation/dissociation kinetics
KW - Rate constants
KW - Radiopharmaceuticals
UR - http://www.sciencedirect.com/science/article/pii/S0277538713005111#
L2 - http://www.sciencedirect.com/science/article/pii/S0277538713005111#
N2 - The kinetic properties of macrocyclic ligand 2-[1,4,7,10-tetraazacyclododecane-1-yl]-ethanethiol (L1, DOSH) were studied with Cu(II) and Zn(II) metal ions, using conventional molecular absorption spectroscopy in pH regions 2.5-4.7 and 4.3-6.0 for Cu(II) and Zn(II), respectively. The obtained partial rate constants, measured at 25 degrees C and ionic strength I = 0.1 M (KCl), are slightly lower than for parent cyclen (1,4,7,10-tetraazacyclododecane) macrocyclic ligand supporting the hypothesis that the thiol pendant arm is not directly involved in the formation of these metal complexes. The study of the dissociation of the copper(II)-L1 complex in the presence of perchloric acid and at higher temperatures (75-95 degrees C) showed that this complex is more kinetically inert than the copper(II) complex with cyclen, indicating that the presence of the thiol pendant arm plays a key role as protecting group of copper(II) ion. On contrary, the dissociation of zinc(II) complex in presence of copper(II) ion measured at laboratory temperature (25 degrees C) and in 0.1 M-solution of hydrochloric acid is going via the metal-exchange reaction mechanism. Altogether, these findings show that L1 ligand presents favorable kinetic properties for further conjugation with biomolecules, aiming at their use in medicinal chemistry.
ER -
ŠEVČÍKOVÁ, Romana, Přemysl LUBAL, Maria Paula Cabral CAMPELLO and Isabel SANTOS. Kinetic study of formation/dissociation of Cu(II) and Zn(II) complexes of cyclen macrocyclic ligand with pendant thiol group. \textit{Polyhedron}. Oxford: Pergamon-Elsevier Science, 2013, vol.~62, OCT 7 2013, p.~268-273. ISSN~0277-5387. Available from: https://dx.doi.org/10.1016/j.poly.2013.06.052.
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