| ŠEVČÍK, Radek, Jakub VANĚK, Přemysl LUBAL, Zuzana KOTKOVÁ, Jan KOTEK and Petr HERMANN. Formation and dissociation kinetics of copper(II) complexes with tetraphosphorus acid DOTA analogs. Polyhedron. Oxford: Pergamon-Elsevier Science, 2014, vol. 67, January, p. 449-455. ISSN 0277-5387. Available from: https://dx.doi.org/10.1016/j.poly.2013.09.024. |
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@article{1164099,
author = {Ševčík, Radek and Vaněk, Jakub and Lubal, Přemysl and Kotková, Zuzana and Kotek, Jan and Hermann, Petr},
article_location = {Oxford},
article_number = {January},
doi = {http://dx.doi.org/10.1016/j.poly.2013.09.024},
keywords = {Macrocyclic ligands; Copper; DOTP ligands; Phosphinate complexes; Phosphonate monoester complexes; Radiopharmaceuticals; Copper isotopes; Cyclen derivatives},
language = {eng},
issn = {0277-5387},
journal = {Polyhedron},
title = {Formation and dissociation kinetics of copper(II) complexes with tetraphosphorus acid DOTA analogs},
url = {http://www.sciencedirect.com/science/article/pii/S0277538713006852#},
volume = {67},
year = {2014}
}
TY - JOUR
ID - 1164099
AU - Ševčík, Radek - Vaněk, Jakub - Lubal, Přemysl - Kotková, Zuzana - Kotek, Jan - Hermann, Petr
PY - 2014
TI - Formation and dissociation kinetics of copper(II) complexes with tetraphosphorus acid DOTA analogs
JF - Polyhedron
VL - 67
IS - January
SP - 449-455
EP - 449-455
PB - Pergamon-Elsevier Science
SN - 02775387
KW - Macrocyclic ligands
KW - Copper
KW - DOTP ligands
KW - Phosphinate complexes
KW - Phosphonate monoester complexes
KW - Radiopharmaceuticals
KW - Copper isotopes
KW - Cyclen derivatives
UR - http://www.sciencedirect.com/science/article/pii/S0277538713006852#
L2 - http://www.sciencedirect.com/science/article/pii/S0277538713006852#
N2 - Thermodynamic and kinetic properties of Cu(II) complexes with macrocyclic cyclen ligands having four phosphonic acid monoester (H4dotpOEt) or four phosphinic acid (H4dotpH) and H4dotpPh) pendant arms were investigated. The formation kinetics carried out in pH range 1-5.5 (t = 25 C, I = 0.1 M KCl) shows that reactive species are (H2L)2- and (HL)3- anions and their reactivity differs by 4-5 orders of magnitude. Among studied ligands, H4dotpH is the most reactive one. Dissociation of these copper(II) complexes was investigated in the presence of perchloric acid (I = 5 M (Na,H)ClO4, proton concentration range 0.1–5.0 M) and in temperature range 10-35 C. All studied complexes are less kinetically inert than the [Cu(dota)]2- complex and the Cu(II) complex of H4dotpH is the least kinetically inert among the studied complexes, probably due to the lowest thermodynamic stability. These results show that the ligands probably cannot be employed for copper radioisotopes complexation but the data will be utilized in design of other macrocyclic ligands intended to be used in medicinal chemistry.
ER -
ŠEVČÍK, Radek, Jakub VANĚK, Přemysl LUBAL, Zuzana KOTKOVÁ, Jan KOTEK and Petr HERMANN. Formation and dissociation kinetics of copper(II) complexes with tetraphosphorus acid DOTA analogs. \textit{Polyhedron}. Oxford: Pergamon-Elsevier Science, 2014, vol.~67, January, p.~449-455. ISSN~0277-5387. Available from: https://dx.doi.org/10.1016/j.poly.2013.09.024.
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