| HEGYI, Hedvig. GABBR1 has a HERV-W LTR in its regulatory region - a possible implication for schizophrenia. BIOLOGY DIRECT. LONDON: BIOMED CENTRAL LTD, 2013, roč. 8, February, s. "nestránkováno", 4 s. ISSN 1745-6150. doi:10.1186/1745-6150-8-5. |
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@article{1165339,
author = {Hegyi, Hedvig},
article_location = {LONDON},
article_number = {February},
doi = {http://dx.doi.org/10.1186/1745-6150-8-5},
keywords = {Schizophrenia; Human endogenous retrovirus; HERV-W; long terminal repeat; LTR; GABA; GABBR1; GABA receptor; Enhancer; Silencer},
language = {eng},
issn = {1745-6150},
journal = {BIOLOGY DIRECT},
title = {GABBR1 has a HERV-W LTR in its regulatory region - a possible implication for schizophrenia},
url = {http://www.biologydirect.com/content/8/1/5},
volume = {8},
year = {2013}
}
TY - JOUR
ID - 1165339
AU - Hegyi, Hedvig
PY - 2013
TI - GABBR1 has a HERV-W LTR in its regulatory region - a possible implication for schizophrenia
JF - BIOLOGY DIRECT
VL - 8
IS - February
SP - "nestránkováno"
EP - "nestránkováno"
PB - BIOMED CENTRAL LTD
SN - 17456150
KW - Schizophrenia
KW - Human endogenous retrovirus
KW - HERV-W
KW - long terminal repeat
KW - LTR
KW - GABA
KW - GABBR1
KW - GABA receptor
KW - Enhancer
KW - Silencer
UR - http://www.biologydirect.com/content/8/1/5
L2 - http://www.biologydirect.com/content/8/1/5
N2 - Schizophrenia is a complex disease with uncertain aetiology. We suggest GABBR1, GABA receptor B1 implicated in schizophrenia based on a HERV-W LTR in the regulatory region of GABBR1. Our hypothesis is supported by: (i) GABBR1 is in the 6p22 genomic region most often implicated in schizophrenia; (ii) microarray studies found that only presynaptic pathway-related genes, including GABA receptors, have altered expression in schizophrenic patients and (iii) it explains how HERV-W elements, expressed in schizophrenia, play a role in the disease: by altering the expression of GABBR1 via a long terminal repeat that is also a regulatory element to GABBR1.
ER -
HEGYI, Hedvig. GABBR1 has a HERV-W LTR in its regulatory region - a possible implication for schizophrenia. \textit{BIOLOGY DIRECT}. LONDON: BIOMED CENTRAL LTD, 2013, roč.~8, February, s.~''nestránkováno'', 4 s. ISSN~1745-6150. doi:10.1186/1745-6150-8-5.
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