HEGYI, Hedvig. GABBR1 has a HERV-W LTR in its regulatory region - a possible implication for schizophrenia. BIOLOGY DIRECT. LONDON: BIOMED CENTRAL LTD, 2013, vol. 8, February, p. "nestránkováno", 4 pp. ISSN 1745-6150. doi:10.1186/1745-6150-8-5.
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Basic information
Original name GABBR1 has a HERV-W LTR in its regulatory region - a possible implication for schizophrenia
Authors HEGYI, Hedvig (348 Hungary, guarantor, belonging to the institution).
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 4.035
RIV identification code RIV/00216224:14740/13:00072067
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1186/1745-6150-8-5
UT WoS 000315729600001
Keywords in English Schizophrenia; Human endogenous retrovirus; HERV-W; long terminal repeat; LTR; GABA; GABBR1; GABA receptor; Enhancer; Silencer
Tags ok, rivok
Tags International impact, Reviewed
Changed by Changed by: Olga Křížová, učo 56639. Changed: 13. 2. 2014 19:28.
Schizophrenia is a complex disease with uncertain aetiology. We suggest GABBR1, GABA receptor B1 implicated in schizophrenia based on a HERV-W LTR in the regulatory region of GABBR1. Our hypothesis is supported by: (i) GABBR1 is in the 6p22 genomic region most often implicated in schizophrenia; (ii) microarray studies found that only presynaptic pathway-related genes, including GABA receptors, have altered expression in schizophrenic patients and (iii) it explains how HERV-W elements, expressed in schizophrenia, play a role in the disease: by altering the expression of GABBR1 via a long terminal repeat that is also a regulatory element to GABBR1.
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
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