WABNIK, Krzysztof, Helene ROBERT BOISIVON, Richard S SMITH and Jiří FRIML. Modeling Framework for the Establishment of the Apical-Basal Embryonic Axis in Plants. Current Biology. Cambridge: CELL PRESS, 2013, vol. 23, No 24, p. 2513-2518. ISSN 0960-9822. doi:10.1016/j.cub.2013.10.038.
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Basic information
Original name Modeling Framework for the Establishment of the Apical-Basal Embryonic Axis in Plants
Authors WABNIK, Krzysztof (56 Belgium), Helene ROBERT BOISIVON (250 France, belonging to the institution), Richard S SMITH (756 Switzerland) and Jiří FRIML (203 Czech Republic, guarantor, belonging to the institution).
Edition Current Biology, Cambridge, CELL PRESS, 2013, 0960-9822.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 9.916
RIV identification code RIV/00216224:14740/13:00072086
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1016/j.cub.2013.10.038
UT WoS 000328918900032
Keywords in English AUXIN TRANSPORT; COMPUTATIONAL MORPHODYNAMICS; ARABIDOPSIS EMBRYOGENESIS; PIN PROTEINS; POLARITY; EXPRESSION; EFFLUX; ABP1; ENDOCYTOSIS; ACTIVATION
Tags ok, rivok
Tags International impact, Reviewed
Changed by Changed by: Olga Křížová, učo 56639. Changed: 13. 2. 2014 20:37.
Abstract
The apical-basal axis of the early plant embryo determines the body plan of the adult organism. To establish a polarized embryonic axis, plants evolved a unique mechanism that involves directional, cell-to-cell transport of the growth regulator auxin. Auxin transport relies on PIN auxin transporters [1], whose polar subcellular localization determines the flow directionality. PIN-mediated auxin transport mediates the spatial and temporal activity of the auxin response machinery [2-7] that contributes to embryo patterning processes, including establishment of the apical (shoot) and basal (root) embryo poles [8]. However, little is known of upstream mechanisms guiding the (re)polarization of auxin fluxes during embryogenesis [9]. Here, we developed a model of plant embryogenesis that correctly generates emergent cell polarities and auxin-mediated sequential initiation of apical-basal axis of plant embryo. The model relies on two precisely localized auxin sources and a feedback between auxin and the polar, subcellular PIN transporter localization. Simulations reproduced PIN polarity and auxin distribution, as well as previously unknown polarization events during early embryogenesis. The spectrum of validated model predictions suggests that our model corresponds to a minimal mechanistic framework for initiation and orientation of the apical-basal axis to guide both embryonic and postembryonic plant development.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
EE2.3.20.0043, research and development projectName: Rozvoj lidských zdrojů pro výzkum, vývoj a inovace v oblasti genomiky a proteomiky rostlinných systémů
EE2.3.30.0037, research and development projectName: Zaměstnáním nejlepších mladých vědců k rozvoji mezinárodní spolupráce
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