Other formats:
BibTeX
LaTeX
RIS
@article{1165387,
author = {Wabnik, Krzysztof and Robert Boisivon, Helene and Smith, Richard S and Friml, Jiří},
article_location = {Cambridge},
article_number = {24},
doi = {http://dx.doi.org/10.1016/j.cub.2013.10.038},
keywords = {AUXIN TRANSPORT; COMPUTATIONAL MORPHODYNAMICS; ARABIDOPSIS EMBRYOGENESIS; PIN PROTEINS; POLARITY; EXPRESSION; EFFLUX; ABP1; ENDOCYTOSIS; ACTIVATION},
language = {eng},
issn = {0960-9822},
journal = {Current Biology},
title = {Modeling Framework for the Establishment of the Apical-Basal Embryonic Axis in Plants},
volume = {23},
year = {2013}
}
TY - JOUR
ID - 1165387
AU - Wabnik, Krzysztof - Robert Boisivon, Helene - Smith, Richard S - Friml, Jiří
PY - 2013
TI - Modeling Framework for the Establishment of the Apical-Basal Embryonic Axis in Plants
JF - Current Biology
VL - 23
IS - 24
SP - 2513-2518
EP - 2513-2518
PB - CELL PRESS
SN - 09609822
KW - AUXIN TRANSPORT
KW - COMPUTATIONAL MORPHODYNAMICS
KW - ARABIDOPSIS EMBRYOGENESIS
KW - PIN PROTEINS
KW - POLARITY
KW - EXPRESSION
KW - EFFLUX
KW - ABP1
KW - ENDOCYTOSIS
KW - ACTIVATION
N2 - The apical-basal axis of the early plant embryo determines the body plan of the adult organism. To establish a polarized embryonic axis, plants evolved a unique mechanism that involves directional, cell-to-cell transport of the growth regulator auxin. Auxin transport relies on PIN auxin transporters [1], whose polar subcellular localization determines the flow directionality. PIN-mediated auxin transport mediates the spatial and temporal activity of the auxin response machinery [2-7] that contributes to embryo patterning processes, including establishment of the apical (shoot) and basal (root) embryo poles [8]. However, little is known of upstream mechanisms guiding the (re)polarization of auxin fluxes during embryogenesis [9]. Here, we developed a model of plant embryogenesis that correctly generates emergent cell polarities and auxin-mediated sequential initiation of apical-basal axis of plant embryo. The model relies on two precisely localized auxin sources and a feedback between auxin and the polar, subcellular PIN transporter localization. Simulations reproduced PIN polarity and auxin distribution, as well as previously unknown polarization events during early embryogenesis. The spectrum of validated model predictions suggests that our model corresponds to a minimal mechanistic framework for initiation and orientation of the apical-basal axis to guide both embryonic and postembryonic plant development.
ER -
WABNIK, Krzysztof, Helene ROBERT BOISIVON, Richard S SMITH and Jiří FRIML. Modeling Framework for the Establishment of the Apical-Basal Embryonic Axis in Plants. \textit{Current Biology}. Cambridge: CELL PRESS, 2013, vol.~23, No~24, p.~2513-2518. ISSN~0960-9822. doi:10.1016/j.cub.2013.10.038.
|
