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@article{1165462,
author = {Fiala, Martin and Wichterle, Dan and Bulková, Veronika and Škňouřil, Libor and Nevřalová, Renata and Toman, Ondřej and Ďorda, Miloslav and Januska, Jaroslav and Špinar, Jindřich},
article_location = {Oxford},
article_number = {1},
doi = {http://dx.doi.org/10.1093/europace/eut161},
keywords = {Atrial fibrillation; Long-standing persistent; Catheter ablation; Outcome},
language = {eng},
issn = {1099-5129},
journal = {Europace},
title = {A prospective evaluation of haemodynamics, functional status, and quality of life after radiofrequency catheter ablation of long-standing persistent atrial fibrillation},
url = {http://europace.oxfordjournals.org/content/16/1/15.short},
volume = {16},
year = {2014}
}
TY - JOUR
ID - 1165462
AU - Fiala, Martin - Wichterle, Dan - Bulková, Veronika - Škňouřil, Libor - Nevřalová, Renata - Toman, Ondřej - Ďorda, Miloslav - Januska, Jaroslav - Špinar, Jindřich
PY - 2014
TI - A prospective evaluation of haemodynamics, functional status, and quality of life after radiofrequency catheter ablation of long-standing persistent atrial fibrillation
JF - Europace
VL - 16
IS - 1
SP - 15-25
EP - 15-25
PB - Oxford University Press
SN - 10995129
KW - Atrial fibrillation
KW - Long-standing persistent
KW - Catheter ablation
KW - Outcome
UR - http://europace.oxfordjournals.org/content/16/1/15.short
L2 - http://europace.oxfordjournals.org/content/16/1/15.short
N2 - Aims Clinical benefit from ablation for long-standing persistent atrial fibrillation has remained unknown. We hypothesized that successful ablation of long-standing persistent atrial fibrillation would improve haemodynamics, functional status, and quality of life. Methods and results A total of 160 patients (aged 59 +/- 9 years, 23% females) undergoing ablation of long-standing (median of 28 months) persistent atrial were enrolled in this prospective study. Morphological and functional echocardiographic parameters, N-terminal prohormone of brain natriuretic peptide (NT-proBNP), maximum oxygen consumption during exercise test (VO2 max), and quality of life were assessed at baseline and 1 year after the ablation. At the 1-year follow-up visit, 81% patients were examined in sinus rhythm (after repeat ablation in 38% patients). Left atrial appendage outflow velocity increased from 44 +/- 20 to 58 +/- 23 cm/s, left ventricular ejection fraction from 54 +/- 9 to 59 +/- 5%, and VO2 max from 20.4 +/- 6.4 to 23.7 +/- 8.1 mL/kg/min; NT-proBNP decreased from median 897 (interquartile range 603 1424) to 230 (interquartile range 120 420) pg/mL (all P < 0.0001). These beneficial effects of ablation were predominantly associated with the presence of sinus rhythm. Quality of life (range 0-100) increased significantly (EQ-5D index: from 68.8 +/- 12.5 to 75.4 +/- 14.4; EQ-VAS score: from 62.8 +/- 13.2 to 70.6 +/- 13.8; both P < 0.0001). Conclusion Ablation of long-standing persistent atrial fibrillation was associated with significant recovery of haemodynamics and exercise capacity that projected onto the long-term improvement in quality of life.
ER -
FIALA, Martin, Dan WICHTERLE, Veronika BULKOVÁ, Libor ŠKŇOUŘIL, Renata NEVŘALOVÁ, Ondřej TOMAN, Miloslav ĎORDA, Jaroslav JANUSKA and Jindřich ŠPINAR. A prospective evaluation of haemodynamics, functional status, and quality of life after radiofrequency catheter ablation of long-standing persistent atrial fibrillation. \textit{Europace}. Oxford: Oxford University Press, 2014, vol.~16, No~1, p.~15-25. ISSN~1099-5129. Available from: https://dx.doi.org/10.1093/europace/eut161.
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