Other formats:
BibTeX
LaTeX
RIS
@article{1166834,
author = {Samanic, Ivica and Simunic, Juraj and Říha, Karel and Puizina, Jasna},
article_number = {10},
doi = {http://dx.doi.org/10.1371/journal.pone.0078760},
keywords = {DOUBLE-STRAND BREAKS; DNA-REPAIR; MEIOTIC RECOMBINATION; HOMOLOGOUS RECOMBINATION; CHROMOSOMAL INSTABILITY; TELOMERE MAINTENANCE; NUCLEASE ACTIVITY; COMPLEX; RAD50; YEAST},
language = {eng},
issn = {1932-6203},
journal = {PLOS ONE},
title = {Evidence for Distinct Functions of MRE11 in Arabidopsis Meiosis},
url = {http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0078760&representation=PDF},
volume = {8},
year = {2013}
}
TY - JOUR
ID - 1166834
AU - Samanic, Ivica - Simunic, Juraj - Říha, Karel - Puizina, Jasna
PY - 2013
TI - Evidence for Distinct Functions of MRE11 in Arabidopsis Meiosis
JF - PLOS ONE
VL - 8
IS - 10
SP - "nestránkováno"
EP - "nestránkováno"
PB - Public Library of Science
SN - 19326203
KW - DOUBLE-STRAND BREAKS
KW - DNA-REPAIR
KW - MEIOTIC RECOMBINATION
KW - HOMOLOGOUS RECOMBINATION
KW - CHROMOSOMAL INSTABILITY
KW - TELOMERE MAINTENANCE
KW - NUCLEASE ACTIVITY
KW - COMPLEX
KW - RAD50
KW - YEAST
UR - http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0078760&representation=PDF
L2 - http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0078760&representation=PDF
N2 - The evolutionary conserved Mre11/Rad50/Nbs1 complex functions as one of the guardians of genome integrity in eukaryotes; it is required for the double-strand break repair, meiosis, DNA checkpoint, and telomere maintenance. To better understand the role of the MRE11 gene in Arabidopsis, we performed comparative analysis of several mre11 alleles with respect to genome stability and meiosis. The mre11-4 and mre11-2 alleles presumably produce truncated MRE11 proteins composed of the first 499 and 529 amino acids, respectively. Although the putative MRE11 truncated proteins differ only by 30 amino acids, the mutants exhibited strikingly different phenotypes in regards to growth morphology, genome stability and meiosis. While the mre11-2 mutants are fully fertile and undergo normal meiosis, the mre11-4 plants are sterile due to aberrant repair of meiotic DNA breaks. Structural homology analysis suggests that the T-DNA insertion in the mre11-4 allele probably disrupted the putative RAD50 interaction and/or homodimerization domain, which is assumed to be preserved in mre11-2 allele. Intriguingly, introgression of the atm-2 mutant plant into the mre11-2 background renders the double mutant infertile, a phenotype not observed in either parent line. This data indicate that MRE11 partially compensates for ATM deficiency in meiosis of Arabidopsis.
ER -
SAMANIC, Ivica, Juraj SIMUNIC, Karel ŘÍHA and Jasna PUIZINA. Evidence for Distinct Functions of MRE11 in Arabidopsis Meiosis. \textit{PLOS ONE}. Public Library of Science, 2013, vol.~8, No~10, p.~''nestránkováno'', 12 pp. ISSN~1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0078760.
|
