CIRCULATING CYTOKINE PATTERN AND FACTORS DESCRIBING RHEUMATOID ARTHRITIS:IL-15 AS ONE OF THE PROGNOSTIC FACTOR OF THE DISEASE PROGRESSION

NĚMEC, Petr, Jolana LIPKOVÁ, Nikolas PÁVEK, Gatterova JINDRA, Miroslav SOUČEK, Anna VAŠKŮ and Monika PÁVKOVÁ GOLDBERGOVÁ. CIRCULATING CYTOKINE PATTERN AND FACTORS DESCRIBING RHEUMATOID ARTHRITIS:IL-15 AS ONE OF THE PROGNOSTIC FACTOR OF THE DISEASE PROGRESSION. In Annual European Congress of Rheumatology EULAR 2013. 2013.

Basic information

• Original name: CIRCULATING CYTOKINE PATTERN AND FACTORS DESCRIBING RHEUMATOID ARTHRITIS:IL-15 AS ONE OF THE PROGNOSTIC FACTOR OF THE DISEASE PROGRESSION
• Name in Czech: Cytokiny v cirkulaci a revmatoidní faktory: IL-15 jako jeden z prognostických faktorů popisujících progresi onemocnění
• Authors: NĚMEC, Petr, Jolana LIPKOVÁ, Nikolas PÁVEK, Gatterova JINDRA, Miroslav SOUČEK, Anna VAŠKŮ and Monika PÁVKOVÁ GOLDBERGOVÁ.
• Edition: Annual European Congress of Rheumatology EULAR 2013, 2013.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Confidentiality degree: is not subject to a state or trade secret
• Organization unit: Faculty of Medicine
• UT WoS: 000331587904432
• Keywords (in Czech): cytokiny, revmatoidní artritida, interleukiny, IL-15
• Keywords in English: cytokines, rheumatoid arthritis, interleukins, IL-15
• Tags: International impact

Abstract

The progression of rheumatoid arthritis (RA) is strongly associated with the immune mechanisms and substances affecting the immune system including chemokines and cytokines.The aim of the study was to examine the relation among polymorphisms and serum levels of selected cytokines (IL-6, IL-13, IL-15), production of autoantibodies, and factors describing activity and progression of RA, such as DAS28 and Total Sharp score. A total of 144 RA patients according to the ACR classification criteria 1987, and 50 control subjects were recruited into the study. The measurements of serum levels of CRP, ACPA, and RFs, radiographs of both hands with calculation of Total Sharp score (TSS), DAS28, and serum levels of cytokines (IL-6, IL-13, IL-15) were obtained from all RA patients. Significant difference in allele frequencies between RA patients and controls was observed for IL-15 -267C/T polymorphism. No significant association of IL-15 gene polymorphisms (367 G/A, 14035 A/T), IL-13 (-1112 C/T), and IL-6 with RA was found. Significant difference between RA patients and controls was observed for IL-15 -267C/T polymorphism in allele frequencies (p = 0.05). Higher prevalence of heterozygote variants of IL-15 14035 A/T and - 267C/T polymorphisms in the RFs negative subgroup (IgG, IgA, IgM; p < 0.05) were observed. The frequency of the T allele of the IL-13 polymorphism C1112T was higher in subgroup with faster progression of the disease (TSS/month 0.1, p = 0.03). In conclusion, we present a correlation of IL-15 gen promoter polymorphisms with the rheumatoid factor subtypes (RF IgG, IgA, IgM) underlined by association with increased levels in circulation.