Inter-regulation of the unfolded protein response and auxin
signaling

J 2014

Inter-regulation of the unfolded protein response and auxin signaling

CHEN, Yani, Kyaw AUNG, Jakub ROLČÍK, Kathryn WALICKI, Jiří FRIML et. al.

Basic information

Original name

Inter-regulation of the unfolded protein response and auxin signaling

Authors

CHEN, Yani (840 United States of America, guarantor), Kyaw AUNG (840 United States of America), Jakub ROLČÍK (203 Czech Republic), Kathryn WALICKI (840 United States of America), Jiří FRIML (203 Czech Republic, belonging to the institution) and Frederica BRANDIZZI (840 United States of America)

Edition

Plant Journal, ENGLAND, Wiley-Blackwell Publishing, Inc. 2014, 0960-7412

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.972

RIV identification code

RIV/00216224:14740/14:00075115

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1111/tpj.12373

UT WoS

000328661300008

Keywords in English

endoplasmic reticulum stress; unfolded protein response; auxin response; IRE1; PIN5; Arabidopsis thaliana

Abstract

V originále

The unfolded protein response (UPR) is a signaling network triggered by overload of protein-folding demand in the endoplasmic reticulum (ER), a condition termed ER stress. The UPR is critical for growth and development; nonetheless, connections between the UPR and other cellular regulatory processes remain largely unknown. Here, we identify a link between the UPR and the phytohormone auxin, a master regulator of plant physiology. We show that ER stress triggers down-regulation of auxin receptors and transporters in Arabidopsis thaliana. We also demonstrate that an Arabidopsis mutant of a conserved ER stress sensor IRE1 exhibits defects in the auxin response and levels. These data not only support that the plant IRE1 is required for auxin homeostasis, they also reveal a species-specific feature of IRE1 in multicellular eukaryotes. Furthermore, by establishing that UPR activation is reduced in mutants of ER-localized auxin transporters, including PIN5, we define a long-neglected biological significance of ER-based auxin regulation. We further examine the functional relationship of IRE1 and PIN5 by showing that an ire1 pin5 triple mutant enhances defects of UPR activation and auxin homeostasis in ire1 or pin5. Our results imply that the plant UPR has evolved a hormone-dependent strategy for coordinating ER function with physiological processes.

Citovat

CHEN, Yani, Kyaw AUNG, Jakub ROLČÍK, Kathryn WALICKI, Jiří FRIML and Frederica BRANDIZZI. Inter-regulation of the unfolded protein response and auxin signaling. Plant Journal. ENGLAND: Wiley-Blackwell Publishing, Inc., 2014, vol. 77, No 1, p. 97-107. ISSN 0960-7412. Available from: https://dx.doi.org/10.1111/tpj.12373.

@article{1168299,
   author = {Chen, Yani and Aung, Kyaw and Rolčík, Jakub and Walicki, Kathryn and Friml, Jiří and Brandizzi, Frederica},
   article_location = {ENGLAND},
   article_number = {1},
   doi = {http://dx.doi.org/10.1111/tpj.12373},
   keywords = {endoplasmic reticulum stress; unfolded protein response; auxin response; IRE1; PIN5; Arabidopsis thaliana},
   language = {eng},
   issn = {0960-7412},
   journal = {Plant Journal},
   title = {Inter-regulation of the unfolded protein response and auxin signaling},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/24180465},
   volume = {77},
   year = {2014}
}

TY  - JOUR
ID  - 1168299
AU  - Chen, Yani - Aung, Kyaw - Rolčík, Jakub - Walicki, Kathryn - Friml, Jiří - Brandizzi, Frederica
PY  - 2014
TI  - Inter-regulation of the unfolded protein response and auxin signaling
JF  - Plant Journal
VL  - 77
IS  - 1
SP  - 97-107
EP  - 97-107
PB  - Wiley-Blackwell Publishing, Inc.
SN  - 09607412
KW  - endoplasmic reticulum stress
KW  - unfolded protein response
KW  - auxin response
KW  - IRE1
KW  - PIN5
KW  - Arabidopsis thaliana
UR  - http://www.ncbi.nlm.nih.gov/pubmed/24180465
L2  - http://www.ncbi.nlm.nih.gov/pubmed/24180465
N2  - The unfolded protein response (UPR) is a signaling network triggered by overload of protein-folding demand in the endoplasmic reticulum (ER), a condition termed ER stress. The UPR is critical for growth and development; nonetheless, connections between the UPR and other cellular regulatory processes remain largely unknown. Here, we identify a link between the UPR and the phytohormone auxin, a master regulator of plant physiology. We show that ER stress triggers down-regulation of auxin receptors and transporters in Arabidopsis thaliana. We also demonstrate that an Arabidopsis mutant of a conserved ER stress sensor IRE1 exhibits defects in the auxin response and levels. These data not only support that the plant IRE1 is required for auxin homeostasis, they also reveal a species-specific feature of IRE1 in multicellular eukaryotes. Furthermore, by establishing that UPR activation is reduced in mutants of ER-localized auxin transporters, including PIN5, we define a long-neglected biological significance of ER-based auxin regulation. We further examine the functional relationship of IRE1 and PIN5 by showing that an ire1 pin5 triple mutant enhances defects of UPR activation and auxin homeostasis in ire1 or pin5. Our results imply that the plant UPR has evolved a hormone-dependent strategy for coordinating ER function with physiological processes.
ER  -

CHEN, Yani, Kyaw AUNG, Jakub ROLČÍK, Kathryn WALICKI, Jiří FRIML and Frederica BRANDIZZI. Inter-regulation of the unfolded protein response and auxin signaling. \textit{Plant Journal}. ENGLAND: Wiley-Blackwell Publishing, Inc., 2014, vol.~77, No~1, p.~97-107. ISSN~0960-7412. Available from: https://dx.doi.org/10.1111/tpj.12373.

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