J 2014

Evaluation of a novel vascular graft with a distal bifurcation designed to reduce the development of intimal hyperplasia. Experimental study in a porcine aorta model

VLACHOVSKÝ, Robert, Robert STAFFA, Martin DVORAK, Michal VLASIN, Markéta HERMANOVÁ et. al.

Basic information

Original name

Evaluation of a novel vascular graft with a distal bifurcation designed to reduce the development of intimal hyperplasia. Experimental study in a porcine aorta model

Authors

VLACHOVSKÝ, Robert (203 Czech Republic, guarantor, belonging to the institution), Robert STAFFA (203 Czech Republic, belonging to the institution), Martin DVORAK (203 Czech Republic), Michal VLASIN (203 Czech Republic), Markéta HERMANOVÁ (203 Czech Republic, belonging to the institution), Thomas O’BRIEN (372 Ireland) and Timothy MCGLOUGHLIN (372 Ireland)

Edition

Biomedical Papers, Olomouc, Palacky University, 2014, 1213-8118

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.200

RIV identification code

RIV/00216224:14110/14:00075119

Organization unit

Faculty of Medicine

DOI

UT WoS

000347173200011

Keywords in English

animal model; anastomosis; graft design; distal bifurcation; intimal hyperplasia; experimental study; pig

Tags

Tags

International impact, Reviewed
Změněno: 24/4/2015 12:42, Soňa Böhmová

Abstract

V originále

Objective. Abnormal haemodynamics is commonly agreed to be a major contributor to the development of distal anastomotic intimal hyperplasia. A new vascular graft design proposed by computational studies was used to demonstrate its surgical feasibility and to compare it with the conventional graft in a porcine model. Method. The device was used in 12 eight-month-old pigs, six received the new graft and six had a conventional graft. The proximal graft end was implanted into the aorta, the distal graft end was implanted into the iliac artery. The host artery was ligated in order to simulate occlusion. At 20 weeks after surgery the pigs were killed and the device was excised for histological and morphometric analysis. Results. In five experimental grafts the reconstruction was occluded due to thrombosis; only one prosthesis was patent showing a minimum of neointimal hyperplasia. In the control group too only three of the six grafts were patent. A histological analysis revealed, as the cause of occlusion, fibrous tissue overgrowth corresponding in structure to neointimal hyperplasia. Differences in the number of obliterations and in occlusion rates between the profiles of the two groups were evaluated using the median test (P<0.05). The results were not statistically significant. Conclusion. Although mathematical modelling had shown significant haemodynamic benefits of a naturally bifurcated graft, our study did not confirm its superiority over conventionally used prostheses.