| SLAMA, Jiri, Karolina ADAMCOVA, Ladislav DUŠEK, Ondrej SOSNA a David CIBULA. Umbilication Is a Strong Predictor of High-Grade Cervical Intraepithelial Neoplasia. JOURNAL OF LOWER GENITAL TRACT DISEASE. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS, 2013, roč. 17, č. 3, s. 303-307. ISSN 1089-2591. Dostupné z: https://dx.doi.org/10.1097/LGT.0b013e31826f2532. |
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@article{1168535,
author = {Slama, Jiri and Adamcova, Karolina and Dušek, Ladislav and Sosna, Ondrej and Cibula, David},
article_location = {PHILADELPHIA},
article_number = {3},
doi = {http://dx.doi.org/10.1097/LGT.0b013e31826f2532},
keywords = {CIN; colposcopy; ridge sign; umbilication; mosaic},
language = {eng},
issn = {1089-2591},
journal = {JOURNAL OF LOWER GENITAL TRACT DISEASE},
title = {Umbilication Is a Strong Predictor of High-Grade Cervical Intraepithelial Neoplasia},
volume = {17},
year = {2013}
}
TY - JOUR
ID - 1168535
AU - Slama, Jiri - Adamcova, Karolina - Dušek, Ladislav - Sosna, Ondrej - Cibula, David
PY - 2013
TI - Umbilication Is a Strong Predictor of High-Grade Cervical Intraepithelial Neoplasia
JF - JOURNAL OF LOWER GENITAL TRACT DISEASE
VL - 17
IS - 3
SP - 303-307
EP - 303-307
PB - LIPPINCOTT WILLIAMS & WILKINS
SN - 10892591
KW - CIN
KW - colposcopy
KW - ridge sign
KW - umbilication
KW - mosaic
N2 - Objective. This study aimed to assess the diagnostic value of the colposcopic feature of umbilication for detecting high-grade cervical intraepithelial neoplasia (CIN 2/3). Materials and Methods. Study included 430 randomly selected women who underwent conization for CIN 2 or CIN 3. The control group consisted of 102 patients with biopsy-confirmed CIN 1. Colpophotographs and reports from colposcopy examinations from all patients were retrospectively analyzed by 2 independent colposcopy experts with the aim to assess the presence of umbilication. The occurence of more than 2 mosaic "tiles" with central punctation was considered to be a positive finding regardless of whether the mosaic pattern was coarse or fine. The prevalence of umbilication in CIN 1 and CIN 2/3 respectively was compared. The diagnostic value of umbilication alone and combination of umbilication and/or ridge sign was assessed. Results. Umbilication was detected in 10% and ridge sign in 10.2% of patients with CIN 2/3. Simultaneous presence of umbilication and ridge sign was rare (1.1%). The umbilication solely reached 12% sensitivity, 100% specificity, and 100% positive predictive value for the detection of underlying CIN 2/3. Conclusions. Umbilication is an age-independent colposcopic feature with very high specificity for predicting CIN 2/3.
ER -
SLAMA, Jiri, Karolina ADAMCOVA, Ladislav DUŠEK, Ondrej SOSNA a David CIBULA. Umbilication Is a Strong Predictor of High-Grade Cervical Intraepithelial Neoplasia. \textit{JOURNAL OF LOWER GENITAL TRACT DISEASE}. PHILADELPHIA: LIPPINCOTT WILLIAMS \&{} WILKINS, 2013, roč.~17, č.~3, s.~303-307. ISSN~1089-2591. Dostupné z: https://dx.doi.org/10.1097/LGT.0b013e31826f2532.
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