RSL lectin - a complex approach to study carbohydrate-protein interaction

HOUSER, Josef, Jiří NOVÁČEK, Jan KOMÁREK, David BUCHTA, Daniel POKORNÝ, Peter BYSTRICKÝ, Lukáš ŽÍDEK and Michaela WIMMEROVÁ. RSL lectin - a complex approach to study carbohydrate-protein interaction. In 12th Discussions in Structural Molecular Biology. 2014. ISSN 1211-5894.

Basic information

• Original name: RSL lectin - a complex approach to study carbohydrate-protein interaction
• Authors: HOUSER, Josef (203 Czech Republic, belonging to the institution), Jiří NOVÁČEK (203 Czech Republic, belonging to the institution), Jan KOMÁREK (203 Czech Republic, belonging to the institution), David BUCHTA (203 Czech Republic, belonging to the institution), Daniel POKORNÝ (203 Czech Republic, belonging to the institution), Peter BYSTRICKÝ (203 Czech Republic, belonging to the institution), Lukáš ŽÍDEK (203 Czech Republic, belonging to the institution) and Michaela WIMMEROVÁ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: 12th Discussions in Structural Molecular Biology, 2014.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 10600 1.6 Biological sciences
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14310/14:00073537
• Organization unit: Faculty of Science
• ISSN: 1211-5894
• Keywords (in Czech): lektin; Ralstonia; AAL rodina
• Keywords in English: lectin; Ralstonia; AAL family

Abstract

In our study we focused on lectin RSL ability to bind alpha and beta methyl fucoside. We combined X-ray crystallography, ITC and NMR to get a complex view on lectin-carbohydrate interaction.

Abstract (in Czech)

V naší studii jsme se zameřili na schopnost lektinu RSL vázat alfa a beta methylfukosid. Použili jsme rentgenovou krystalografii, ITC a NMR, abychom získali komplexní pohled na interakci lektin-sacharid.

Links

• CZ.1.05/1.1.00/02.0068, interní kód MU: Name: CEITEC - středoevropský technologický institut (Acronym: CEITEC)

Investor: Ministry of Education, Youth and Sports of the CR, CEITEC - Central European Institute of Technology, 1.1 European Centres of Excellence

• GA13-25401S, research and development project: Name: Studium proteinů z patogenů zapojených do rozpoznávání hostitelského organismu

Investor: Czech Science Foundation

• LH13055, research and development project: Name: Multidisciplinární přístup k návrhu léčiv - Inhibice proteinů s návazností na cukry (Acronym: MADICA)

Investor: Ministry of Education, Youth and Sports of the CR

• 286154, interní kód MU: Name: SYLICA - Synergies of Life and Material Sciences to Create a New Future (Acronym: SYLICA)

Investor: European Union, Capacities