SOBOLČIAK, Patrik, Mário ŠPÍREK, Jaroslav KATRLÍK, Peter GEMEINER, Igor LACÍK and Peter KASÁK. Light-Switchable Polymer from Cationic to Zwitterionic Form: Synthesis, Characterization, and Interactions with DNA and Bacterial Cells. MACROMOLECULAR RAPID COMMUNICATIONS. 2013, vol. 34, No 8, p. 635-639. ISSN 1022-1336. Available from: https://dx.doi.org/10.1002/marc.201200823. |
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@article{1170156, author = {Sobolčiak, Patrik and Špírek, Mário and Katrlík, Jaroslav and Gemeiner, Peter and Lacík, Igor and Kasák, Peter}, article_number = {8}, doi = {http://dx.doi.org/10.1002/marc.201200823}, keywords = {antibacterial; carboxybetaine ester; dsDNA polyplex; photochemistry; water-soluble polymers}, language = {eng}, issn = {1022-1336}, journal = {MACROMOLECULAR RAPID COMMUNICATIONS}, title = {Light-Switchable Polymer from Cationic to Zwitterionic Form: Synthesis, Characterization, and Interactions with DNA and Bacterial Cells}, volume = {34}, year = {2013} }
TY - JOUR ID - 1170156 AU - Sobolčiak, Patrik - Špírek, Mário - Katrlík, Jaroslav - Gemeiner, Peter - Lacík, Igor - Kasák, Peter PY - 2013 TI - Light-Switchable Polymer from Cationic to Zwitterionic Form: Synthesis, Characterization, and Interactions with DNA and Bacterial Cells JF - MACROMOLECULAR RAPID COMMUNICATIONS VL - 34 IS - 8 SP - 635-639 EP - 635-639 SN - 10221336 KW - antibacterial KW - carboxybetaine ester KW - dsDNA polyplex KW - photochemistry KW - water-soluble polymers N2 - A novel cationic polymer poly(N,N-dimethyl-N-[3-(methacroylamino) propyl]-N-[2-[(2-nitrophenyl)methoxy]-2-oxo-ethyl]ammonium chloride) is synthesized by free-radical polymerization of N-[3-(dimethylamino)propyl] methacrylamide and subsequent quaternization with o-nitrobenzyl 2-chloroacetate. The photolabile o-nitrobenzyl carboxymethyl pendant moiety is transformed to the zwitterionic carboxybetaine form upon the irradiation at 365 nm. This feature is used to condense and, upon the light irradiation, to release double-strand DNA tested by gel electrophoresis and surface plasmon resonance experiments as well as to switch the antibacterial activity to non-toxic character demonstrated for Escherichia coli bacterial cells in solution and at the surface using the self-assembled monolayers. ER -
SOBOLČIAK, Patrik, Mário ŠPÍREK, Jaroslav KATRLÍK, Peter GEMEINER, Igor LACÍK and Peter KASÁK. Light-Switchable Polymer from Cationic to Zwitterionic Form: Synthesis, Characterization, and Interactions with DNA and Bacterial Cells. \textit{MACROMOLECULAR RAPID COMMUNICATIONS}. 2013, vol.~34, No~8, p.~635-639. ISSN~1022-1336. Available from: https://dx.doi.org/10.1002/marc.201200823.
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