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@proceedings{1173268,
author = {Paroulek, Petr and Rájecký, Michal and Pěnčíková, Kristýna and Táborský, Petr},
booktitle = {European symposium on atomic spectrometry ESAS 2014 & 15th Czech-Slovak spectroscopic conference},
keywords = {benzo[c]phenanthridine alkaloids; G-quadruplex; circular dichroism},
isbn = {978-80-905704-1-2},
title = {Study of interaction of benzo[c]phenanthridine alkaloids with DNA},
year = {2014}
}
TY - CONF
ID - 1173268
AU - Paroulek, Petr - Rájecký, Michal - Pěnčíková, Kristýna - Táborský, Petr
PY - 2014
TI - Study of interaction of benzo[c]phenanthridine alkaloids with DNA
SN - 9788090570412
KW - benzo[c]phenanthridine alkaloids
KW - G-quadruplex
KW - circular dichroism
N2 - G-quadruplex (GQ) is one of non-canonical structures of nucleic acids (NA). Structures of intramolecular GQs (formed by only one strand of NA) can be distinguished into two groups according to sequence orientation: parallel and anti-parallel GQs [1]. The effect of selected benzo[c]phenanthridine and protoberberine alkaloids from plants of Papaveraceae family [2] on stability of parallel (sequence from c- kit oncogene promoter) and anti-parallel (human telomeric sequence) GQ was studied. Stabilization (in terms of melting point shifts) of GQs by interaction with macarpine, sanguilutine, sanguinarubine, sanguinarine, chelerythrine and corysamine was followed by UV-vis and CD spectrometry. Results showed that all tested alkaloids except macarpine have a stabilizing effect on human telomeric sequence (∆T m = 3-17 °C). Parallel sequence from c-kit oncogene promoter was stabilized by all alkaloids.
ER -
PAROULEK, Petr, Michal RÁJECKÝ, Kristýna PĚNČÍKOVÁ a Petr TÁBORSKÝ. Study of interaction of benzo[c]phenanthridine alkaloids with DNA. In \textit{European symposium on atomic spectrometry ESAS 2014 \&{} 15th Czech-Slovak spectroscopic conference}. 2014. ISBN~978-80-905704-1-2.
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