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@article{1173452,
author = {Jabandžiev, Petr and Smerek, Michal and Michalek, Jaroslav Sr. and Fedora, Michal and Košinová, Lucie and Hubacek, Jaroslav A. and Michálek, Jaroslav},
article_location = {LONDON},
article_number = {1},
doi = {http://dx.doi.org/10.1186/cc13174},
keywords = {sepsis; children; gene; single nucleotide polymorphism},
language = {eng},
issn = {1466-609X},
journal = {Critical Care},
title = {Multiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis},
url = {http://ccforum.com/content/pdf/cc13174.pdf},
volume = {18},
year = {2014}
}
TY - JOUR
ID - 1173452
AU - Jabandžiev, Petr - Smerek, Michal - Michalek, Jaroslav Sr. - Fedora, Michal - Košinová, Lucie - Hubacek, Jaroslav A. - Michálek, Jaroslav
PY - 2014
TI - Multiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis
JF - Critical Care
VL - 18
IS - 1
SP - 1-9
EP - 1-9
PB - BioMed Central
SN - 1466609X
KW - sepsis
KW - children
KW - gene
KW - single nucleotide polymorphism
UR - http://ccforum.com/content/pdf/cc13174.pdf
N2 - Introduction: The aim of the study was to identify the dependency structure of genetic variants that can influence the outcome for paediatric patients with sepsis. Methods: We evaluated the role of single nucleotide polymorphisms for five genes: bactericidal permeability increasing protein (BPI; rs5743507), lipopolysaccharide-binding protein (LBP; rs2232618), toll-like receptor 4 (TLR4; rs4986790), heat shock protein 70 (HSP 70; rs2227956), and interleukin 6 (IL-6; rs1800795) in 598 children aged 0 to 19 years that were admitted to a paediatric intensive care unit with fever, systemic inflammatory response syndrome, sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome. A control group of 529 healthy individuals was included. Multi-way contingency tables were constructed and statistically evaluated using log-linear models. Typical gene combinations were found for both study groups. Results: Detailed analyses of the five studied gene profiles revealed significant differences in sepsis survival. Stratification into high-risk, intermediate-risk, and low-risk groups of paediatric patients can predict the severity of sepsis. Conclusions: Analysis of single nucleotide polymorphisms for five genes can be used as a predictor of sepsis outcome in children.
ER -
JABANDŽIEV, Petr, Michal SMEREK, Jaroslav Sr. MICHALEK, Michal FEDORA, Lucie KOŠINOVÁ, Jaroslav A. HUBACEK and Jaroslav MICHÁLEK. Multiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis. \textit{Critical Care}. LONDON: BioMed Central, 2014, vol.~18, No~1, p.~1-9. ISSN~1466-609X. Available from: https://dx.doi.org/10.1186/cc13174.
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