POTLUKOVA, Eliska, Tomáš FREIBERGER, Zdenka LIMANOVA, Jan JISKRA, Zdenek TELICKA, Jana BARTAKOVA, Drahomira SPRINGER, Hana VITKOVA and Marten TRENDELENBURG. Association between Low Levels of Mannan-Binding Lectin and Markers of Autoimmune Thyroid Disease in Pregnancy. PLoS One. PUBLIC LIBRARY SCIENCE, 2013, vol. 8, No 12, p. "e81755-1"-"e81755-7", 7 pp. ISSN 1932-6203. doi:10.1371/journal.pone.0081755.
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Basic information
Original name Association between Low Levels of Mannan-Binding Lectin and Markers of Autoimmune Thyroid Disease in Pregnancy
Authors POTLUKOVA, Eliska (203 Czech Republic), Tomáš FREIBERGER (203 Czech Republic, guarantor, belonging to the institution), Zdenka LIMANOVA (203 Czech Republic), Jan JISKRA (203 Czech Republic), Zdenek TELICKA (203 Czech Republic), Jana BARTAKOVA (203 Czech Republic), Drahomira SPRINGER (203 Czech Republic), Hana VITKOVA (203 Czech Republic) and Marten TRENDELENBURG (756 Switzerland).
Edition PLoS One, PUBLIC LIBRARY SCIENCE, 2013, 1932-6203.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30201 Cardiac and Cardiovascular systems
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 3.534
RIV identification code RIV/00216224:14740/13:00072793
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1371/journal.pone.0081755
UT WoS 000328707400037
Keywords in English SYSTEMIC-LUPUS-ERYTHEMATOSUS; GENE POLYMORPHISMS; MBL2 GENE; APOPTOTIC CELLS; ASTHMA; DEFICIENCY; CHILDREN; GENOTYPES; PREECLAMPSIA; INFECTIONS
Tags ok, podil, rivok
Tags International impact, Reviewed
Changed by Changed by: Olga Křížová, učo 56639. Changed: 15. 4. 2014 10:04.
Abstract
Functional deficiency of mannan-binding lectin (MBL) has been associated with adverse pregnancy outcome. Adverse events during pregnancy have also been described in women with autoimmune thyroid diseases (AITD), and thyroid hormones have been shown to influence serum levels of MBL. Therefore, the aim of this study was to analyse the impact of MBL-deficiency on the outcome of pregnancy in relation to the presence of AITD. Almost one year after delivery, we assessed serum MBL levels and MBL2-genotypes in 212 women positively screened for AITD in pregnancy. In 103 of these women, we could also measure MBL levels in frozen serum samples from the 9-12th gestational week, obtaining 96 pairs of MBL values (pregnancy vs. follow-up). As controls, 80 sera of pregnant women screened negatively for AITD were used. MBL2-genotyping was performed using multiplex PCR. Women with thyroid dysfunction and/or thyroid peroxidase antibodies (TPOAb) had lower MBL levels during pregnancy than controls, (3275 vs. 5000 ng/ml, p<0.05). The lowest levels were found in women with elevated thyroid-stimulating hormone (TSH) levels in the absence of TPOAb (2207 ng/ml; p<0.01 as compared to controls). MBL2 genotype distribution did not differ between subgroups. At a median follow-up period of 17 months (range: 3-78 months) after delivery, median MBL level had decreased further to 1923 ng/ml (p<0.0001) without significant changes in TSH. In an explorative survey, functional MBL-deficiency was neither linked to a history of spontaneous abortion, nor other obstetric complications, severe infections throughout life/pregnancy or antibiotics use in pregnancy. In conclusion, hypothyroidism during pregnancy is associated with decreased MBL levels, and the levels decreased further after delivery.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
EE2.3.20.0045, research and development projectName: Podpora profesního růstu a mezinárodní integrace výzkumných týmů v oblasti molekulární medicíny
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