Detailed Information on Publication Record
2013
Influence of cerebellar stereotactic stimulation on left-right electrodermal information transference in a patient with cerebral palsy
BOB, Petr, Tomas GALANDA, Peter JOMBÍK, Jiří RABOCH, Miroslav GALANDA et. al.Basic information
Original name
Influence of cerebellar stereotactic stimulation on left-right electrodermal information transference in a patient with cerebral palsy
Authors
BOB, Petr (203 Czech Republic, guarantor, belonging to the institution), Tomas GALANDA (703 Slovakia), Peter JOMBÍK (703 Slovakia), Jiří RABOCH (203 Czech Republic) and Miroslav GALANDA (703 Slovakia)
Edition
Neuropsychiatric Disease and Treatment, Aukland, Dove Medical Press, 2013, 1176-6328
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30000 3. Medical and Health Sciences
Country of publisher
New Zealand
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 2.154
RIV identification code
RIV/00216224:14740/13:00072795
Organization unit
Central European Institute of Technology
UT WoS
000327739700001
Keywords in English
autonomic laterality; bilateral electrodermal activity; cerebral palsy; epileptiform activity; interhemispheric interaction; stereotactic cerebellar stimulation
Tags
International impact, Reviewed
Změněno: 30/3/2014 21:52, Olga Křížová
Abstract
V originále
Background and objectives: Recent evidence indicates that cerebral palsy is connected to specific autonomic dysregulation between sympathetic and parasympathetic efferent pathways, likely linked to hemispheric influences. These findings suggest a hypothesis that contralateral interhemispheric disinhibition, which may occur on various levels of brain processing including motor functions, could be linked to specific functional dysregulation and structural lesions, which may play a specific role in the modulation of autonomic functions and lead to autonomic dysregulation in cerebral palsy. Method: With the aim of comparing autonomic functions as they relate to interhemispheric modulatory influences during therapeutically indicated stereotactic cerebellar stimulation, we have performed bilateral electrodermal activity measurement and calculations of pointwise transinformation (PTI) in a patient with cerebral palsy. Measurement was performed during therapeutic deep cerebellar stimulation in two cerebellar areas in anterior cerebellar lobe-culmen (left electrode) and central lobule-superior cerebellar peduncle (right electrode). Results: The results indicate that information transference (PTI) is able to distinguish the states related to specific cerebellar stimulations and that lowest levels of the PTI have been found during stimulation of the central lobule-superior cerebellar peduncle (electrode deepest contact 1), indicating a significantly increased level of inhibition between the left and right sides. Conclusion: The results may present potentially useful clinical findings indicating that increased PTI calculated from electrodermal activity could indirectly indicate disinhibitory activity as a possible indicator of a failure of interhemispheric communication that could explain some specific pathogenetic mechanisms in cerebral palsy. Nevertheless, these results need detailed confirmation in further research, as well as reliable clinical evaluation of their usefulness in the therapy of cerebral palsy.
Links
| ED1.1.00/02.0068, research and development project |
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