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@article{1173746,
author = {Bob, Petr and Galanda, Tomas and Jombík, Peter and Raboch, Jiří and Galanda, Miroslav},
article_location = {Aukland},
article_number = {Nov},
doi = {http://dx.doi.org/10.2147/NDT.S52947},
keywords = {autonomic laterality; bilateral electrodermal activity; cerebral palsy; epileptiform activity; interhemispheric interaction; stereotactic cerebellar stimulation},
language = {eng},
issn = {1176-6328},
journal = {Neuropsychiatric Disease and Treatment},
title = {Influence of cerebellar stereotactic stimulation on left-right electrodermal information transference in a patient with cerebral palsy},
url = {http://www.dovepress.com/influence-of-cerebellar-stereotactic-stimulation-on-leftndashright-ele-peer-reviewed-article-NDT},
volume = {9},
year = {2013}
}
TY - JOUR
ID - 1173746
AU - Bob, Petr - Galanda, Tomas - Jombík, Peter - Raboch, Jiří - Galanda, Miroslav
PY - 2013
TI - Influence of cerebellar stereotactic stimulation on left-right electrodermal information transference in a patient with cerebral palsy
JF - Neuropsychiatric Disease and Treatment
VL - 9
IS - Nov
SP - 1853-1857
EP - 1853-1857
PB - Dove Medical Press
SN - 11766328
KW - autonomic laterality
KW - bilateral electrodermal activity
KW - cerebral palsy
KW - epileptiform activity
KW - interhemispheric interaction
KW - stereotactic cerebellar stimulation
UR - http://www.dovepress.com/influence-of-cerebellar-stereotactic-stimulation-on-leftndashright-ele-peer-reviewed-article-NDT
L2 - http://www.dovepress.com/influence-of-cerebellar-stereotactic-stimulation-on-leftndashright-ele-peer-reviewed-article-NDT
N2 - Background and objectives: Recent evidence indicates that cerebral palsy is connected to specific autonomic dysregulation between sympathetic and parasympathetic efferent pathways, likely linked to hemispheric influences. These findings suggest a hypothesis that contralateral interhemispheric disinhibition, which may occur on various levels of brain processing including motor functions, could be linked to specific functional dysregulation and structural lesions, which may play a specific role in the modulation of autonomic functions and lead to autonomic dysregulation in cerebral palsy. Method: With the aim of comparing autonomic functions as they relate to interhemispheric modulatory influences during therapeutically indicated stereotactic cerebellar stimulation, we have performed bilateral electrodermal activity measurement and calculations of pointwise transinformation (PTI) in a patient with cerebral palsy. Measurement was performed during therapeutic deep cerebellar stimulation in two cerebellar areas in anterior cerebellar lobe-culmen (left electrode) and central lobule-superior cerebellar peduncle (right electrode). Results: The results indicate that information transference (PTI) is able to distinguish the states related to specific cerebellar stimulations and that lowest levels of the PTI have been found during stimulation of the central lobule-superior cerebellar peduncle (electrode deepest contact 1), indicating a significantly increased level of inhibition between the left and right sides. Conclusion: The results may present potentially useful clinical findings indicating that increased PTI calculated from electrodermal activity could indirectly indicate disinhibitory activity as a possible indicator of a failure of interhemispheric communication that could explain some specific pathogenetic mechanisms in cerebral palsy. Nevertheless, these results need detailed confirmation in further research, as well as reliable clinical evaluation of their usefulness in the therapy of cerebral palsy.
ER -
BOB, Petr, Tomas GALANDA, Peter JOMBÍK, Jiří RABOCH and Miroslav GALANDA. Influence of cerebellar stereotactic stimulation on left-right electrodermal information transference in a patient with cerebral palsy. \textit{Neuropsychiatric Disease and Treatment}. Aukland: Dove Medical Press, 2013, vol.~9, Nov, p.~1853-1857. ISSN~1176-6328. Available from: https://dx.doi.org/10.2147/NDT.S52947.
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