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@article{1173911,
author = {Kuricová, Katarína and Dvořáková, Veronika and Pácal, Lukáš and Bartáková, Vendula and Brožová, Lucie and Jarkovský, Jiří and Kaňková, Kateřina},
article_number = {1},
doi = {http://dx.doi.org/10.1159/000355757},
keywords = {Diabetic nephropathy; Nitric oxide synthase; Polymorphism; Cardiovascular morbidity},
language = {eng},
issn = {1420-4096},
journal = {Kidney and Blood Pressure Research},
title = {NOS3 894G > T Polymorphism is Associated With Progression of Kidney Disease and Cardiovascular Morbidity in Type 2 Diabetic Patients: NOS3 as a Modifier Gene for Diabetic Nephropathy?},
url = {http://www.karger.com/Article/Pdf/355757},
volume = {38},
year = {2014}
}
TY - JOUR
ID - 1173911
AU - Kuricová, Katarína - Dvořáková, Veronika - Pácal, Lukáš - Bartáková, Vendula - Brožová, Lucie - Jarkovský, Jiří - Kaňková, Kateřina
PY - 2014
TI - NOS3 894G > T Polymorphism is Associated With Progression of Kidney Disease and Cardiovascular Morbidity in Type 2 Diabetic Patients: NOS3 as a Modifier Gene for Diabetic Nephropathy?
JF - Kidney and Blood Pressure Research
VL - 38
IS - 1
SP - 92-98
EP - 92-98
PB - Karger
SN - 14204096
KW - Diabetic nephropathy
KW - Nitric oxide synthase
KW - Polymorphism
KW - Cardiovascular morbidity
UR - http://www.karger.com/Article/Pdf/355757
N2 - Background/Aims: We have previously associated SNP 894G>T in the NOS3 gene with diabetic nephropathy (DN) using multi-locus analysis. Variant 894G>T has been widely studied as a DN susceptibility factor with contradictory results. In the present study we genotyped 894G>T in the cohort of prospectively followed type 2 diabetics with the aim to investigate its possible role in the progression of DN and development of morbidity and mortality associated with diabetes. Methods: 311 subjects with defined stage of DN were enrolled in the study and followed up for a median of 38 months. We considered three end-points: progression of DN, major cardiovascular event and all-cause mortality. Results: Considering baseline GFR, age at enrolment and diabetes duration as confounders, Cox regression analysis identified 894GTgenotype as a risk factor for DN progression (HR = 1.843 [95% CI 1.088 – 3.119], P = 0.023) and 894TT genotype as a risk factor for major cardiovascular event (HR = 2.515 [95% CI 1.060 – 5.965], P = 0.036). Conclusion: We ascertained the significant effect of the NOS3 894G>T variant on DN progression and occurrence of major cardiovascular event in T2DM subjects. Based on these results NOS3 can be considered a modifier gene for DN.
ER -
KURICOVÁ, Katarína, Veronika DVOŘÁKOVÁ, Lukáš PÁCAL, Vendula BARTÁKOVÁ, Lucie BROŽOVÁ, Jiří JARKOVSKÝ a Kateřina KAŇKOVÁ. NOS3 894G \&{}gt; T Polymorphism is Associated With Progression of Kidney Disease and Cardiovascular Morbidity in Type 2 Diabetic Patients: NOS3 as a Modifier Gene for Diabetic Nephropathy? \textit{Kidney and Blood Pressure Research}. Karger, roč.~38, č.~1, s.~92-98. ISSN~1420-4096. doi:10.1159/000355757. 2014.
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