NOS3 894G > T Polymorphism is Associated With Progression of
Kidney Disease and Cardiovascular Morbidity in Type 2 Diabetic
Patients: NOS3 as a Modifier Gene for Diabetic Nephropathy?

J 2014

NOS3 894G > T Polymorphism is Associated With Progression of Kidney Disease and Cardiovascular Morbidity in Type 2 Diabetic Patients: NOS3 as a Modifier Gene for Diabetic Nephropathy?

KURICOVÁ, Katarína, Veronika DVOŘÁKOVÁ, Lukáš PÁCAL, Vendula BARTÁKOVÁ, Lucie BROŽOVÁ et. al.

Basic information

Original name

NOS3 894G > T Polymorphism is Associated With Progression of Kidney Disease and Cardiovascular Morbidity in Type 2 Diabetic Patients: NOS3 as a Modifier Gene for Diabetic Nephropathy?

Authors

KURICOVÁ, Katarína (703 Slovakia, belonging to the institution), Veronika DVOŘÁKOVÁ (203 Czech Republic, belonging to the institution), Lukáš PÁCAL (203 Czech Republic, guarantor, belonging to the institution), Vendula BARTÁKOVÁ (203 Czech Republic, belonging to the institution), Lucie BROŽOVÁ (203 Czech Republic, belonging to the institution), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution) and Kateřina KAŇKOVÁ (203 Czech Republic, belonging to the institution)

Edition

Kidney and Blood Pressure Research, Karger, 2014, 1420-4096

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.123

RIV identification code

RIV/00216224:14110/14:00080127

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1159/000355757

UT WoS

000334181300010

Keywords in English

Diabetic nephropathy; Nitric oxide synthase; Polymorphism; Cardiovascular morbidity

Abstract

V originále

Background/Aims: We have previously associated SNP 894G>T in the NOS3 gene with diabetic nephropathy (DN) using multi-locus analysis. Variant 894G>T has been widely studied as a DN susceptibility factor with contradictory results. In the present study we genotyped 894G>T in the cohort of prospectively followed type 2 diabetics with the aim to investigate its possible role in the progression of DN and development of morbidity and mortality associated with diabetes. Methods: 311 subjects with defined stage of DN were enrolled in the study and followed up for a median of 38 months. We considered three end-points: progression of DN, major cardiovascular event and all-cause mortality. Results: Considering baseline GFR, age at enrolment and diabetes duration as confounders, Cox regression analysis identified 894GTgenotype as a risk factor for DN progression (HR = 1.843 [95% CI 1.088 – 3.119], P = 0.023) and 894TT genotype as a risk factor for major cardiovascular event (HR = 2.515 [95% CI 1.060 – 5.965], P = 0.036). Conclusion: We ascertained the significant effect of the NOS3 894G>T variant on DN progression and occurrence of major cardiovascular event in T2DM subjects. Based on these results NOS3 can be considered a modifier gene for DN.

Links

NT11405, research and development project

Name: Mikrobiologické a genetické determinanty rozvoje a progrese parodontitidy u diabetiků 1. a 2. typu a jejich reciproční vztah ke kompenzaci diabetu

Investor: Ministry of Health of the CR

Citovat

KURICOVÁ, Katarína, Veronika DVOŘÁKOVÁ, Lukáš PÁCAL, Vendula BARTÁKOVÁ, Lucie BROŽOVÁ, Jiří JARKOVSKÝ and Kateřina KAŇKOVÁ. NOS3 894G > T Polymorphism is Associated With Progression of Kidney Disease and Cardiovascular Morbidity in Type 2 Diabetic Patients: NOS3 as a Modifier Gene for Diabetic Nephropathy? Kidney and Blood Pressure Research. Karger, 2014, vol. 38, No 1, p. 92-98. ISSN 1420-4096. Available from: https://dx.doi.org/10.1159/000355757.

@article{1173911,
   author = {Kuricová, Katarína and Dvořáková, Veronika and Pácal, Lukáš and Bartáková, Vendula and Brožová, Lucie and Jarkovský, Jiří and Kaňková, Kateřina},
   article_number = {1},
   doi = {http://dx.doi.org/10.1159/000355757},
   keywords = {Diabetic nephropathy; Nitric oxide synthase; Polymorphism; Cardiovascular morbidity},
   language = {eng},
   issn = {1420-4096},
   journal = {Kidney and Blood Pressure Research},
   title = {NOS3 894G > T Polymorphism is Associated With Progression of Kidney Disease and Cardiovascular Morbidity in Type 2 Diabetic Patients: NOS3 as a Modifier Gene for Diabetic Nephropathy?},
   url = {http://www.karger.com/Article/Pdf/355757},
   volume = {38},
   year = {2014}
}

TY  - JOUR
ID  - 1173911
AU  - Kuricová, Katarína - Dvořáková, Veronika - Pácal, Lukáš - Bartáková, Vendula - Brožová, Lucie - Jarkovský, Jiří - Kaňková, Kateřina
PY  - 2014
TI  - NOS3 894G > T Polymorphism is Associated With Progression of Kidney Disease and Cardiovascular Morbidity in Type 2 Diabetic Patients: NOS3 as a Modifier Gene for Diabetic Nephropathy?
JF  - Kidney and Blood Pressure Research
VL  - 38
IS  - 1
SP  - 92-98
EP  - 92-98
PB  - Karger
SN  - 14204096
KW  - Diabetic nephropathy
KW  - Nitric oxide synthase
KW  - Polymorphism
KW  - Cardiovascular morbidity
UR  - http://www.karger.com/Article/Pdf/355757
N2  - Background/Aims: We have previously associated SNP 894G>T in the NOS3 gene with diabetic nephropathy (DN) using multi-locus analysis. Variant 894G>T has been widely studied as a DN susceptibility factor with contradictory results. In the present study we genotyped 894G>T in the cohort of prospectively followed type 2 diabetics with the aim to investigate its possible role in the progression of DN and development of morbidity and mortality associated with diabetes. Methods: 311 subjects with defined stage of DN were enrolled in the study and followed up for a median of 38 months. We considered three end-points: progression of DN, major cardiovascular event and all-cause mortality. Results: Considering baseline GFR, age at enrolment and diabetes duration as confounders, Cox regression analysis identified 894GTgenotype as a risk factor for DN progression (HR = 1.843 [95% CI 1.088 – 3.119], P = 0.023) and 894TT genotype as a risk factor for major cardiovascular event (HR = 2.515 [95% CI 1.060 – 5.965], P = 0.036). Conclusion: We ascertained the significant effect of the NOS3 894G>T variant on DN progression and occurrence of major cardiovascular event in T2DM subjects. Based on these results NOS3 can be considered a modifier gene for DN.
ER  -

KURICOVÁ, Katarína, Veronika DVOŘÁKOVÁ, Lukáš PÁCAL, Vendula BARTÁKOVÁ, Lucie BROŽOVÁ, Jiří JARKOVSKÝ and Kateřina KAŇKOVÁ. NOS3 894G \&{}gt; T Polymorphism is Associated With Progression of Kidney Disease and Cardiovascular Morbidity in Type 2 Diabetic Patients: NOS3 as a Modifier Gene for Diabetic Nephropathy? \textit{Kidney and Blood Pressure Research}. Karger, 2014, vol.~38, No~1, p.~92-98. ISSN~1420-4096. Available from: https://dx.doi.org/10.1159/000355757.

Detailed Information on Publication Record