Other formats:
BibTeX
LaTeX
RIS
@article{1173973,
author = {Nováček, Jiří and Žídek, Lukáš and Sklenář, Vladimír},
article_location = {San Diego},
article_number = {April},
doi = {http://dx.doi.org/10.1016/j.jmr.2013.12.008},
keywords = {IDPs; IDPRs; Multi-dimensional NMR; Non-uniform sampling; NUS; PRE; RDC; RNAP delta-subunit},
language = {eng},
issn = {1090-7807},
journal = {Journal of Magnetic Resonance},
title = {Toward optimal-resolution NMR of intrinsically disordered proteins},
url = {http://dx.doi.org/10.1016/j.jmr.2013.12.008},
volume = {241},
year = {2014}
}
TY - JOUR
ID - 1173973
AU - Nováček, Jiří - Žídek, Lukáš - Sklenář, Vladimír
PY - 2014
TI - Toward optimal-resolution NMR of intrinsically disordered proteins
JF - Journal of Magnetic Resonance
VL - 241
IS - April
SP - 41-52
EP - 41-52
PB - Academic Press Inc Elsevier Science
SN - 10907807
KW - IDPs
KW - IDPRs
KW - Multi-dimensional NMR
KW - Non-uniform sampling
KW - NUS
KW - PRE
KW - RDC
KW - RNAP delta-subunit
UR - http://dx.doi.org/10.1016/j.jmr.2013.12.008
L2 - http://dx.doi.org/10.1016/j.jmr.2013.12.008
N2 - Proteins, which, in their native conditions, sample a multitude of distinct conformational states characterized by high spatiotemporal heterogeneity, most often termed as intrinsically disordered proteins (IDPs), have become a target of broad interest over the past 15 years. With the growing evidence of their important roles in fundamental cellular processes, there is an urgent need to characterize the conformational behavior of IDPs at the highest possible level. The unique feature of NMR spectroscopy in the context of IDPs is its ability to supply details of their structural and temporal alterations at atomic-level resolution. Here, we briefly review recently proposed NMR-based strategies to characterize transient states populated by IDPs and summarize the latest achievements and future prospects in methodological development. Because low chemical shift dispersion represents the major obstacle encountered when studying IDPs by nuclear magnetic resonance, particular attention is paid to techniques allowing one to approach the physical limits of attainable resolution.
ER -
NOVÁČEK, Jiří, Lukáš ŽÍDEK and Vladimír SKLENÁŘ. Toward optimal-resolution NMR of intrinsically disordered proteins. \textit{Journal of Magnetic Resonance}. San Diego: Academic Press Inc Elsevier Science, 2014, vol.~241, April, p.~41-52. ISSN~1090-7807. Available from: https://dx.doi.org/10.1016/j.jmr.2013.12.008.
|
