DARZENTAS, Nikos and Kostas STAMATOPOULOS. Stereotyped B Cell Receptors in B Cell Leukemias and Lymphomas. In Ralf Küppers. Lymphoma. Vol. 971. London: Humana Press, 2013, p. 135-148. Methods in Molecular Biology. ISBN 978-1-62703-268-1. Available from: https://dx.doi.org/10.1007/978-1-62703-269-8_8.
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Basic information
Original name Stereotyped B Cell Receptors in B Cell Leukemias and Lymphomas
Authors DARZENTAS, Nikos (300 Greece, guarantor, belonging to the institution) and Kostas STAMATOPOULOS (300 Greece).
Edition Vol. 971. London, Lymphoma, p. 135-148, 14 pp. Methods in Molecular Biology, 2013.
Publisher Humana Press
Other information
Original language English
Type of outcome Chapter(s) of a specialized book
Field of Study 30200 3.2 Clinical medicine
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Publication form printed version "print"
RIV identification code RIV/00216224:14740/13:00072871
Organization unit Central European Institute of Technology
ISBN 978-1-62703-268-1
Doi http://dx.doi.org/10.1007/978-1-62703-269-8_8
Keywords in English B cell receptor; Immunoglobulin gene; CDR3; antigen; pattern; stereotypy; bioinformatics
Tags ok, rivok
Tags International impact, Reviewed
Changed by Changed by: Olga Křížová, učo 56639. Changed: 8/4/2014 11:24.
Abstract
Recent research has revealed the existence of subsets (clusters) of patients with different types of B-cell lymphomas and leukemias with restricted, “stereotyped” immunoglobulin (IG) variable heavy complementarity-determining region 3 (VH CDR3) sequences within their B cell receptors (BcR), suggesting selection by common epitopes or classes of structurally similar epitopes. BcR stereotypy was initially described in chronic lymphocytic leukemia (CLL), where it constitutes a remarkably frequent feature of the IG repertoire, and subsequently identified in other malignancies, including mantle cell lymphoma and splenic marginal-zone lymphoma. Of note, at least in CLL, emerging evidence indicates that the grouping of cases into distinct clusters with stereotyped BcR is functionally and prognostically relevant. Hence, the reliable identification of BcR stereotypy may assist in the investigation of the nature of the selecting antigens and immune pathways leading to lymphoma development, and also potentially pave the way for tailored treatment strategies applicable to each major stereotyped subset. In this chapter, we provide an overview of BcR stereotypy in human B-cell malignancies, and outline previous and current methodological approaches used for its identification.
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