Composition and effects of inhalable size fractions of
atmospheric aerosols in the polluted atmosphere. Part II. In
vitro biological potencies

J 2014

Composition and effects of inhalable size fractions of atmospheric aerosols in the polluted atmosphere. Part II. In vitro biological potencies

NOVÁK, Jiří; Klára HILSCHEROVÁ; Linda LANDLOVÁ; Pavel ČUPR; Lukáš KOHÚT et al.

Základní údaje

Originální název

Composition and effects of inhalable size fractions of atmospheric aerosols in the polluted atmosphere. Part II. In vitro biological potencies

Autoři

NOVÁK, Jiří; Klára HILSCHEROVÁ; Linda LANDLOVÁ; Pavel ČUPR; Lukáš KOHÚT; John P GIESY a Jana KLÁNOVÁ

Vydání

Environment International, OXFORD, ENGLAND, PERGAMON-ELSEVIER SCIENCE LTD, 2014, 0160-4120

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10511 Environmental sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 5.559

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/14:00073576

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

PM size fractions; Dioxin-like toxicity; Estrogenicity; Antiandrogenicity; Genotoxicity

Štítky

AKR, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 28. 1. 2015 15:42, Ing. Andrea Mikešková

Anotace

V originále

Exposure to particulate matter (PM) in ambient air has been shown to lead to adverse health consequences. Six size fractions of PM with aerodynamic diameter smaller than 10 mu m (PM10) and gas phase were collected at six localities with different major pollution sources. Extracts of samples were assessed for AhR-mediated toxicity, (anti-)estrogenicity, (anti-)androgenicity and genotoxicity. The biological responses were interpreted relative to chemical characterization. Historically, for regulatory purposes, evaluation of air pollution was based mainly on assessment of the sum of PM10. In the case of AhR-mediated activity, PM1 was responsible for more than 75% of the activity of the particulate fraction from all localities. The assessed effects were correlated with concentrations of polycyclic aromatic hydrocarbons (PAH), organic carbon content and specific surface area of the PM. A significant proportion of biologically active chemicals seems to be present in the gas phase of air. The results suggest that an average daily exposure based just on the concentrations of contaminants contained in PM10, as regulated in EU legislation so far, is not a sufficient indicator of contaminants in air particulates and adoption of standards more similar to other countries and inclusion of other parameters besides mass should be considered.

Návaznosti

ED0001/01/01, projekt VaV

Název: CETOCOEN

GPP503/10/P249, projekt VaV

Název: Stanovení sady biologických efektů atmosferických polutantů in vitro

Investor: Grantová agentura ČR, Stanovení sady biologických efektů atmosferických polutantů in vitro

Citovat

NOVÁK, Jiří; Klára HILSCHEROVÁ; Linda LANDLOVÁ; Pavel ČUPR; Lukáš KOHÚT; John P GIESY a Jana KLÁNOVÁ. Composition and effects of inhalable size fractions of atmospheric aerosols in the polluted atmosphere. Part II. In vitro biological potencies. Environment International. OXFORD, ENGLAND: PERGAMON-ELSEVIER SCIENCE LTD, 2014, roč. 63, february, s. 64-70. ISSN 0160-4120. Dostupné z: https://doi.org/10.1016/j.envint.2013.10.013.

@article{1174143,
   author = {Novák, Jiří and Hilscherová, Klára and Landlová, Linda and Čupr, Pavel and Kohút, Lukáš and Giesy, John P and Klánová, Jana},
   article_location = {OXFORD, ENGLAND},
   article_number = {february},
   doi = {https://doi.org/10.1016/j.envint.2013.10.013},
   keywords = {PM size fractions; Dioxin-like toxicity; Estrogenicity; Antiandrogenicity; Genotoxicity},
   language = {eng},
   issn = {0160-4120},
   journal = {Environment International},
   title = {Composition and effects of inhalable size fractions of atmospheric aerosols in the polluted atmosphere. Part II. In vitro biological potencies},
   volume = {63},
   year = {2014}
}

TY  - JOUR
ID  - 1174143
AU  - Novák, Jiří - Hilscherová, Klára - Landlová, Linda - Čupr, Pavel - Kohút, Lukáš - Giesy, John P - Klánová, Jana
PY  - 2014
TI  - Composition and effects of inhalable size fractions of atmospheric aerosols in the polluted atmosphere. Part II. In vitro biological potencies
JF  - Environment International
VL  - 63
IS  - february
SP  - 64-70
EP  - 64-70
PB  - PERGAMON-ELSEVIER SCIENCE LTD
SN  - 01604120
KW  - PM size fractions
KW  - Dioxin-like toxicity
KW  - Estrogenicity
KW  - Antiandrogenicity
KW  - Genotoxicity
N2  - Exposure to particulate matter (PM) in ambient air has been shown to lead to adverse health consequences. Six size fractions of PM with aerodynamic diameter smaller than 10 mu m (PM10) and gas phase were collected at six localities with different major pollution sources. Extracts of samples were assessed for AhR-mediated toxicity, (anti-)estrogenicity, (anti-)androgenicity and genotoxicity. The biological responses were interpreted relative to chemical characterization. Historically, for regulatory purposes, evaluation of air pollution was based mainly on assessment of the sum of PM10. In the case of AhR-mediated activity, PM1 was responsible for more than 75% of the activity of the particulate fraction from all localities. The assessed effects were correlated with concentrations of polycyclic aromatic hydrocarbons (PAH), organic carbon content and specific surface area of the PM. A significant proportion of biologically active chemicals seems to be present in the gas phase of air. The results suggest that an average daily exposure based just on the concentrations of contaminants contained in PM10, as regulated in EU legislation so far, is not a sufficient indicator of contaminants in air particulates and adoption of standards more similar to other countries and inclusion of other parameters besides mass should be considered.
ER  -

NOVÁK, Jiří; Klára HILSCHEROVÁ; Linda LANDLOVÁ; Pavel ČUPR; Lukáš KOHÚT; John P GIESY a Jana KLÁNOVÁ. Composition and effects of inhalable size fractions of atmospheric aerosols in the polluted atmosphere. Part II. In vitro biological potencies. \textit{Environment International}. OXFORD, ENGLAND: PERGAMON-ELSEVIER SCIENCE LTD, 2014, roč.~63, february, s.~64-70. ISSN~0160-4120. Dostupné z: https://doi.org/10.1016/j.envint.2013.10.013.

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