First evidence of independent pseudogenization of Toll-like
receptor 5 in passerine birds

J 2014

First evidence of independent pseudogenization of Toll-like receptor 5 in passerine birds

BAINOVÁ, Hana, Tereza KRÁLOVÁ, Anna BRYJOVÁ, Tomáš ALBRECHT, Josef BRYJA et. al.

Basic information

Original name

First evidence of independent pseudogenization of Toll-like receptor 5 in passerine birds

Authors

BAINOVÁ, Hana (203 Czech Republic, guarantor), Tereza KRÁLOVÁ (203 Czech Republic, belonging to the institution), Anna BRYJOVÁ (203 Czech Republic), Tomáš ALBRECHT (203 Czech Republic), Josef BRYJA (203 Czech Republic, belonging to the institution) and Michal VINKLER (203 Czech Republic)

Edition

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, England, 2014, 0145-305X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10600 1.6 Biological sciences

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.815

RIV identification code

RIV/00216224:14310/14:00082007

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.dci.2014.02.010

UT WoS

000335624800016

Keywords in English

Birds; Expression; Innate immunity; Toll-like receptor 5; Pseudogene; Flagellin

Abstract

V originále

Toll-like receptor 5 (TLR5) is a Pattern-recognition receptor responsible for microbial flagellin detection in vertebrates and, hence, recognition of potentially pathogenic bacteria. Herein, we report emergence of TLR5 pseudogene in several phylogenetic lineages of passerine birds (Aves: Passeriformes). Out of 47 species examined in this study 18 possessed a TLR5 pseudogene. Phylogenetic analysis together with the type of mutation responsible for pseudogenization indicate that TLR5 pseudogene emerged at least seven times independently in passerines. Lack of any functional copy of the gene has been verified based on TLR5 mRNA blood expression in four species representing the four main passerine lineages possessing the TLR5 pseudogene. Our results suggest that the non-functional TLR5 variant is fixed in those lineages or, at least, that individuals homozygote in the TLR5 pseudogene are frequent in the investigated species. Further research is needed to assess the impact of the TLR5 loss on immunological performance in birds.

Citovat

BAINOVÁ, Hana, Tereza KRÁLOVÁ, Anna BRYJOVÁ, Tomáš ALBRECHT, Josef BRYJA and Michal VINKLER. First evidence of independent pseudogenization of Toll-like receptor 5 in passerine birds. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY. England, 2014, vol. 45, No 1, p. 151-155. ISSN 0145-305X. Available from: https://dx.doi.org/10.1016/j.dci.2014.02.010.

@article{1180262,
   author = {Bainová, Hana and Králová, Tereza and Bryjová, Anna and Albrecht, Tomáš and Bryja, Josef and Vinkler, Michal},
   article_location = {England},
   article_number = {1},
   doi = {http://dx.doi.org/10.1016/j.dci.2014.02.010},
   keywords = {Birds; Expression; Innate immunity; Toll-like receptor 5; Pseudogene; Flagellin},
   language = {eng},
   issn = {0145-305X},
   journal = {DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY},
   title = {First evidence of independent pseudogenization of Toll-like receptor 5 in passerine birds},
   volume = {45},
   year = {2014}
}

TY  - JOUR
ID  - 1180262
AU  - Bainová, Hana - Králová, Tereza - Bryjová, Anna - Albrecht, Tomáš - Bryja, Josef - Vinkler, Michal
PY  - 2014
TI  - First evidence of independent pseudogenization of Toll-like receptor 5 in passerine birds
JF  - DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
VL  - 45
IS  - 1
SP  - 151-155
EP  - 151-155
SN  - 0145305X
KW  - Birds
KW  - Expression
KW  - Innate immunity
KW  - Toll-like receptor 5
KW  - Pseudogene
KW  - Flagellin
N2  - Toll-like receptor 5 (TLR5) is a Pattern-recognition receptor responsible for microbial flagellin detection in vertebrates and, hence, recognition of potentially pathogenic bacteria. Herein, we report emergence of TLR5 pseudogene in several phylogenetic lineages of passerine birds (Aves: Passeriformes). Out of 47 species examined in this study 18 possessed a TLR5 pseudogene. Phylogenetic analysis together with the type of mutation responsible for pseudogenization indicate that TLR5 pseudogene emerged at least seven times independently in passerines. Lack of any functional copy of the gene has been verified based on TLR5 mRNA blood expression in four species representing the four main passerine lineages possessing the TLR5 pseudogene. Our results suggest that the non-functional TLR5 variant is fixed in those lineages or, at least, that individuals homozygote in the TLR5 pseudogene are frequent in the investigated species. Further research is needed to assess the impact of the TLR5 loss on immunological performance in birds.
ER  -

BAINOVÁ, Hana, Tereza KRÁLOVÁ, Anna BRYJOVÁ, Tomáš ALBRECHT, Josef BRYJA and Michal VINKLER. First evidence of independent pseudogenization of Toll-like receptor 5 in passerine birds. \textit{DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY}. England, 2014, vol.~45, No~1, p.~151-155. ISSN~0145-305X. Available from: https://dx.doi.org/10.1016/j.dci.2014.02.010.

Detailed Information on Publication Record