PINO, Samanta, Giovanna COSTANZO, Alessandra GIORGI, Jiří ŠPONER, Judit ŠPONEROVÁ and Ernesto DI MAURO. Ribozyme Activity of RNA Nonenzymatically Polymerized from 3 ',5 '-Cyclic GMP. Entropy. Basel: MDPI AG, 2013, vol. 15, No 12, p. 5362-5383. ISSN 1099-4300. Available from: https://dx.doi.org/10.3390/e15125362. |
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@article{1180347, author = {Pino, Samanta and Costanzo, Giovanna and Giorgi, Alessandra and Šponer, Jiří and Šponerová, Judit and Di Mauro, Ernesto}, article_location = {Basel}, article_number = {12}, doi = {http://dx.doi.org/10.3390/e15125362}, keywords = {RNA; RNA polymerization; RNA origin; ribozymes; origin of life}, language = {eng}, issn = {1099-4300}, journal = {Entropy}, title = {Ribozyme Activity of RNA Nonenzymatically Polymerized from 3 ',5 '-Cyclic GMP}, url = {http://www.mdpi.com/1099-4300/15/12/5362}, volume = {15}, year = {2013} }
TY - JOUR ID - 1180347 AU - Pino, Samanta - Costanzo, Giovanna - Giorgi, Alessandra - Šponer, Jiří - Šponerová, Judit - Di Mauro, Ernesto PY - 2013 TI - Ribozyme Activity of RNA Nonenzymatically Polymerized from 3 ',5 '-Cyclic GMP JF - Entropy VL - 15 IS - 12 SP - 5362-5383 EP - 5362-5383 PB - MDPI AG SN - 10994300 KW - RNA KW - RNA polymerization KW - RNA origin KW - ribozymes KW - origin of life UR - http://www.mdpi.com/1099-4300/15/12/5362 L2 - http://www.mdpi.com/1099-4300/15/12/5362 N2 - 3',5'-Cyclic GMP spontaneously nonenzymatically polymerizes in a base-catalyzed reaction affording G oligonucleotides. When reacted with fully or partially sequence-complementary RNA (oligo C), the abiotically generated oligo G RNA displays a typical ribozyme activity consisting of terminal ligation accompanied by cleavage of an internal phosphate site of the donor oligonucleotide stem upon attack of the acceptor 3' terminal OH. This reaction is dubbed Ligation following Intermolecular Cleavage (LIC). In a prebiotic perspective, the ability of oligo G polynucleotides to react with other sequences outlines a simple and possible evolutionary scenario based on the autocatalytic properties of RNA. ER -
PINO, Samanta, Giovanna COSTANZO, Alessandra GIORGI, Jiří ŠPONER, Judit ŠPONEROVÁ and Ernesto DI MAURO. Ribozyme Activity of RNA Nonenzymatically Polymerized from 3 ',5 '-Cyclic GMP. \textit{Entropy}. Basel: MDPI AG, 2013, vol.~15, No~12, p.~5362-5383. ISSN~1099-4300. Available from: https://dx.doi.org/10.3390/e15125362.
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