Ribozyme Activity of RNA Nonenzymatically Polymerized from 3
',5 '-Cyclic GMP

J 2013

Ribozyme Activity of RNA Nonenzymatically Polymerized from 3 ',5 '-Cyclic GMP

PINO, Samanta, Giovanna COSTANZO, Alessandra GIORGI, Jiří ŠPONER, Judit ŠPONEROVÁ et. al.

Basic information

Original name

Ribozyme Activity of RNA Nonenzymatically Polymerized from 3 ',5 '-Cyclic GMP

Authors

PINO, Samanta (380 Italy), Giovanna COSTANZO (380 Italy), Alessandra GIORGI (380 Italy), Jiří ŠPONER (203 Czech Republic, guarantor, belonging to the institution), Judit ŠPONEROVÁ (348 Hungary, belonging to the institution) and Ernesto DI MAURO (380 Italy)

Edition

Entropy, Basel, MDPI AG, 2013, 1099-4300

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10610 Biophysics

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.564

RIV identification code

RIV/00216224:14740/13:00073063

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.3390/e15125362

UT WoS

000330339700014

Keywords in English

RNA; RNA polymerization; RNA origin; ribozymes; origin of life

Abstract

V originále

3',5'-Cyclic GMP spontaneously nonenzymatically polymerizes in a base-catalyzed reaction affording G oligonucleotides. When reacted with fully or partially sequence-complementary RNA (oligo C), the abiotically generated oligo G RNA displays a typical ribozyme activity consisting of terminal ligation accompanied by cleavage of an internal phosphate site of the donor oligonucleotide stem upon attack of the acceptor 3' terminal OH. This reaction is dubbed Ligation following Intermolecular Cleavage (LIC). In a prebiotic perspective, the ability of oligo G polynucleotides to react with other sequences outlines a simple and possible evolutionary scenario based on the autocatalytic properties of RNA.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

Citovat

PINO, Samanta, Giovanna COSTANZO, Alessandra GIORGI, Jiří ŠPONER, Judit ŠPONEROVÁ and Ernesto DI MAURO. Ribozyme Activity of RNA Nonenzymatically Polymerized from 3 ',5 '-Cyclic GMP. Entropy. Basel: MDPI AG, 2013, vol. 15, No 12, p. 5362-5383. ISSN 1099-4300. Available from: https://dx.doi.org/10.3390/e15125362.

@article{1180347,
   author = {Pino, Samanta and Costanzo, Giovanna and Giorgi, Alessandra and Šponer, Jiří and Šponerová, Judit and Di Mauro, Ernesto},
   article_location = {Basel},
   article_number = {12},
   doi = {http://dx.doi.org/10.3390/e15125362},
   keywords = {RNA; RNA polymerization; RNA origin; ribozymes; origin of life},
   language = {eng},
   issn = {1099-4300},
   journal = {Entropy},
   title = {Ribozyme Activity of RNA Nonenzymatically Polymerized from 3 ',5 '-Cyclic GMP},
   url = {http://www.mdpi.com/1099-4300/15/12/5362},
   volume = {15},
   year = {2013}
}

TY  - JOUR
ID  - 1180347
AU  - Pino, Samanta - Costanzo, Giovanna - Giorgi, Alessandra - Šponer, Jiří - Šponerová, Judit - Di Mauro, Ernesto
PY  - 2013
TI  - Ribozyme Activity of RNA Nonenzymatically Polymerized from 3 ',5 '-Cyclic GMP
JF  - Entropy
VL  - 15
IS  - 12
SP  - 5362-5383
EP  - 5362-5383
PB  - MDPI AG
SN  - 10994300
KW  - RNA
KW  - RNA polymerization
KW  - RNA origin
KW  - ribozymes
KW  - origin of life
UR  - http://www.mdpi.com/1099-4300/15/12/5362
L2  - http://www.mdpi.com/1099-4300/15/12/5362
N2  - 3',5'-Cyclic GMP spontaneously nonenzymatically polymerizes in a base-catalyzed reaction affording G oligonucleotides. When reacted with fully or partially sequence-complementary RNA (oligo C), the abiotically generated oligo G RNA displays a typical ribozyme activity consisting of terminal ligation accompanied by cleavage of an internal phosphate site of the donor oligonucleotide stem upon attack of the acceptor 3' terminal OH. This reaction is dubbed Ligation following Intermolecular Cleavage (LIC). In a prebiotic perspective, the ability of oligo G polynucleotides to react with other sequences outlines a simple and possible evolutionary scenario based on the autocatalytic properties of RNA.
ER  -

PINO, Samanta, Giovanna COSTANZO, Alessandra GIORGI, Jiří ŠPONER, Judit ŠPONEROVÁ and Ernesto DI MAURO. Ribozyme Activity of RNA Nonenzymatically Polymerized from 3 ',5 '-Cyclic GMP. \textit{Entropy}. Basel: MDPI AG, 2013, vol.~15, No~12, p.~5362-5383. ISSN~1099-4300. Available from: https://dx.doi.org/10.3390/e15125362.

Detailed Information on Publication Record