| PINO, Samanta, Giovanna COSTANZO, Alessandra GIORGI, Jiří ŠPONER, Judit ŠPONEROVÁ and Ernesto DI MAURO. Ribozyme Activity of RNA Nonenzymatically Polymerized from 3 ',5 '-Cyclic GMP. Entropy. Basel: MDPI AG, 2013, vol. 15, No 12, p. 5362-5383. ISSN 1099-4300. Available from: https://dx.doi.org/10.3390/e15125362. |
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@article{1180347,
author = {Pino, Samanta and Costanzo, Giovanna and Giorgi, Alessandra and Šponer, Jiří and Šponerová, Judit and Di Mauro, Ernesto},
article_location = {Basel},
article_number = {12},
doi = {http://dx.doi.org/10.3390/e15125362},
keywords = {RNA; RNA polymerization; RNA origin; ribozymes; origin of life},
language = {eng},
issn = {1099-4300},
journal = {Entropy},
title = {Ribozyme Activity of RNA Nonenzymatically Polymerized from 3 ',5 '-Cyclic GMP},
url = {http://www.mdpi.com/1099-4300/15/12/5362},
volume = {15},
year = {2013}
}
TY - JOUR
ID - 1180347
AU - Pino, Samanta - Costanzo, Giovanna - Giorgi, Alessandra - Šponer, Jiří - Šponerová, Judit - Di Mauro, Ernesto
PY - 2013
TI - Ribozyme Activity of RNA Nonenzymatically Polymerized from 3 ',5 '-Cyclic GMP
JF - Entropy
VL - 15
IS - 12
SP - 5362-5383
EP - 5362-5383
PB - MDPI AG
SN - 10994300
KW - RNA
KW - RNA polymerization
KW - RNA origin
KW - ribozymes
KW - origin of life
UR - http://www.mdpi.com/1099-4300/15/12/5362
L2 - http://www.mdpi.com/1099-4300/15/12/5362
N2 - 3',5'-Cyclic GMP spontaneously nonenzymatically polymerizes in a base-catalyzed reaction affording G oligonucleotides. When reacted with fully or partially sequence-complementary RNA (oligo C), the abiotically generated oligo G RNA displays a typical ribozyme activity consisting of terminal ligation accompanied by cleavage of an internal phosphate site of the donor oligonucleotide stem upon attack of the acceptor 3' terminal OH. This reaction is dubbed Ligation following Intermolecular Cleavage (LIC). In a prebiotic perspective, the ability of oligo G polynucleotides to react with other sequences outlines a simple and possible evolutionary scenario based on the autocatalytic properties of RNA.
ER -
PINO, Samanta, Giovanna COSTANZO, Alessandra GIORGI, Jiří ŠPONER, Judit ŠPONEROVÁ and Ernesto DI MAURO. Ribozyme Activity of RNA Nonenzymatically Polymerized from 3 ',5 '-Cyclic GMP. \textit{Entropy}. Basel: MDPI AG, 2013, vol.~15, No~12, p.~5362-5383. ISSN~1099-4300. Available from: https://dx.doi.org/10.3390/e15125362.
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