J 2014

The effect of the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) on behavioural sensitisation to methamphetamine in mice

LANDA, Leoš, Karel ŠLAIS, Alena MÁCHALOVÁ and Alexandra ŠULCOVÁ

Basic information

Original name

The effect of the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) on behavioural sensitisation to methamphetamine in mice

Authors

LANDA, Leoš (203 Czech Republic), Karel ŠLAIS (203 Czech Republic, belonging to the institution), Alena MÁCHALOVÁ (203 Czech Republic, belonging to the institution) and Alexandra ŠULCOVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Veterinární medicína, Praha, CZECH ACADEMY AGRICULTURAL SCIENCES, 2014, 0375-8427

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 0.639

RIV identification code

RIV/00216224:14740/14:00075341

Organization unit

Central European Institute of Technology

UT WoS

000339609700005

Keywords in English

behavioural sensitisation; methamphetamine; cannabinoids; ACPA; mice

Tags

International impact, Reviewed
Změněno: 28/8/2015 07:31, Olga Křížová

Abstract

V originále

The psychostimulant methamphetamine (Met), similarly to other drugs of abuse, is known to pro-duce an increased behavioural response after its repeated application (behavioural sensitisation). It has also been described that an increased response to a drug may be elicited by previous repeated administration of another drug (cross-sensitisation). We have previously shown that the CB1, CB2 and TRPV (vanilloid) cannabinoid receptor agonist methanandamide, cross-sensitised to Met stimulatory effects in mice. The present study was focused on ability of the more selective and potent CB1 receptor activator arachidonylcyclopropylamide (ACPA) to elicit cross-sensitisation to the stimulatory effects of Met on mouse locomotor behaviour in the Open field test. Male mice were randomly divided into three groups and on seven occasions (from the 7th to 13th day of the experiment) were administered drugs as follows:(a) n1: vehicle at the dose of 10 ml/kg/day; (b) n2: Met at the dose of 2.5 mg/kg/day; (c) n 3: ACPA at the dose of 1.0 mg/kg/day. Locomotor behaviour in the Open field test was measured (a) after administration of vehicle on the 1st experimental day, (b) after the 1st dose of drugs given on the 7th day, and (c) on the 14th day after drugs as follows:(a) n1: vehicle at the dose of 10 ml/kg/day; (b) n2: Met at the dose of 2.5 mg/kg/day; (c) n 3: ACPA at the dose of 1.0 mg/kg/day.

Links

ED1.1.00/02.0068, research and development project
Name: CEITEC - central european institute of technology