Detailed Information on Publication Record
2014
The effect of the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) on behavioural sensitisation to methamphetamine in mice
LANDA, Leoš, Karel ŠLAIS, Alena MÁCHALOVÁ and Alexandra ŠULCOVÁBasic information
Original name
The effect of the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) on behavioural sensitisation to methamphetamine in mice
Authors
LANDA, Leoš (203 Czech Republic), Karel ŠLAIS (203 Czech Republic, belonging to the institution), Alena MÁCHALOVÁ (203 Czech Republic, belonging to the institution) and Alexandra ŠULCOVÁ (203 Czech Republic, guarantor, belonging to the institution)
Edition
Veterinární medicína, Praha, CZECH ACADEMY AGRICULTURAL SCIENCES, 2014, 0375-8427
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30104 Pharmacology and pharmacy
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 0.639
RIV identification code
RIV/00216224:14740/14:00075341
Organization unit
Central European Institute of Technology
UT WoS
000339609700005
Keywords in English
behavioural sensitisation; methamphetamine; cannabinoids; ACPA; mice
Tags
Tags
International impact, Reviewed
Změněno: 28/8/2015 07:31, Olga Křížová
Abstract
V originále
The psychostimulant methamphetamine (Met), similarly to other drugs of abuse, is known to pro-duce an increased behavioural response after its repeated application (behavioural sensitisation). It has also been described that an increased response to a drug may be elicited by previous repeated administration of another drug (cross-sensitisation). We have previously shown that the CB1, CB2 and TRPV (vanilloid) cannabinoid receptor agonist methanandamide, cross-sensitised to Met stimulatory effects in mice. The present study was focused on ability of the more selective and potent CB1 receptor activator arachidonylcyclopropylamide (ACPA) to elicit cross-sensitisation to the stimulatory effects of Met on mouse locomotor behaviour in the Open field test. Male mice were randomly divided into three groups and on seven occasions (from the 7th to 13th day of the experiment) were administered drugs as follows:(a) n1: vehicle at the dose of 10 ml/kg/day; (b) n2: Met at the dose of 2.5 mg/kg/day; (c) n 3: ACPA at the dose of 1.0 mg/kg/day. Locomotor behaviour in the Open field test was measured (a) after administration of vehicle on the 1st experimental day, (b) after the 1st dose of drugs given on the 7th day, and (c) on the 14th day after drugs as follows:(a) n1: vehicle at the dose of 10 ml/kg/day; (b) n2: Met at the dose of 2.5 mg/kg/day; (c) n 3: ACPA at the dose of 1.0 mg/kg/day.
Links
ED1.1.00/02.0068, research and development project |
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