Další formáty:
BibTeX
LaTeX
RIS
@article{1180402,
author = {Terzian, Ana Luisa B. and Micale, Vincenzo and Wotjak, Carsten T.},
article_location = {Hoboken},
article_number = {1},
doi = {http://dx.doi.org/10.1111/ejn.12561},
keywords = {cannabinoid 1 receptor; glutamic acid; rimonabant; animal experiment; article; brain nerve cell; controlled study; exploratory behavior; female; GABAergic system; glutamatergic nerve cell; interneuron; male; mouse; nonhuman; priority journal},
language = {eng},
issn = {0953-816X},
journal = {European Journal of Neuroscience},
title = {Cannabinoid receptor type 1 receptors on GABAergic vs. glutamatergic neurons differentially gate sex-dependent social interest in mice},
url = {http://onlinelibrary.wiley.com/doi/10.1111/ejn.12561/pdf},
volume = {40},
year = {2014}
}
TY - JOUR
ID - 1180402
AU - Terzian, Ana Luisa B. - Micale, Vincenzo - Wotjak, Carsten T.
PY - 2014
TI - Cannabinoid receptor type 1 receptors on GABAergic vs. glutamatergic neurons differentially gate sex-dependent social interest in mice
JF - European Journal of Neuroscience
VL - 40
IS - 1
SP - 2293-2298
EP - 2293-2298
PB - WILEY-BLACKWELL
SN - 0953816X
KW - cannabinoid 1 receptor
KW - glutamic acid
KW - rimonabant
KW - animal experiment
KW - article
KW - brain nerve cell
KW - controlled study
KW - exploratory behavior
KW - female
KW - GABAergic system
KW - glutamatergic nerve cell
KW - interneuron
KW - male
KW - mouse
KW - nonhuman
KW - priority journal
UR - http://onlinelibrary.wiley.com/doi/10.1111/ejn.12561/pdf
L2 - http://onlinelibrary.wiley.com/doi/10.1111/ejn.12561/pdf
N2 - Abnormalities in social behavior are found in almost all psychiatric disorders, such as anxiety, depression, autism, and schizophrenia. Thus, comprehension of the neurobiological basis of social interaction is important for a better understanding of numerous pathologies and improved treatments. Several findings have suggested that an alteration of cannabinoid receptor type 1 (CB1) receptor function could be involved in the pathophysiology of such disorders. However, the role of CB1 receptors is still unclear, and their localisation on different neuronal subpopulations may produce distinct outcomes. To dissect the role of CB1 receptors in different neuronal populations, we used male knockout mice and their respective control littermates [total deletion (CB1-/- ); specific deletion on cortical glutamatergic neurons (Glu-CB1-/- ) or on GABAergic interneurons (GABA-CB1-/- ), and wild-type (WT) mice treated with the CB1 antagonist/inverse agonist SR141716A (3 mg/kg). Mice were required to perform different social tasks - direct social interaction and social investigation. Direct interaction of two male mice was not modified in any group; however, when they were paired with females, Glu-CB1-/- mice showed reduced interaction. Also, exploration of the male stimulus subject in the three-chamber social investigation test was almost unaffected. The situation was completely different when a female was used as the stimulus subject. In this case, Glu-CB1-/- mice showed reduced interest in the social stimulus, mimicking the phenotype of CB1-/- or WT mice treated with SR141716A. GABA-CB1-/- mice showed the opposite phenotype, by spending more time investigating the social stimulus. In conclusion, we provide evidence that CB1 receptors specifically modulate the social investigation of female mice in a neuronal subtype-specific manner.
ER -
TERZIAN, Ana Luisa B., Vincenzo MICALE a Carsten T. WOTJAK. Cannabinoid receptor type 1 receptors on GABAergic vs. glutamatergic neurons differentially gate sex-dependent social interest in mice. Online. \textit{European Journal of Neuroscience}. Hoboken: WILEY-BLACKWELL, 2014, roč.~40, č.~1, s.~2293-2298. ISSN~0953-816X. Dostupné z: https://dx.doi.org/10.1111/ejn.12561. [citováno 2024-04-23]
|
