PASTIERIK, Tomáš, Peter ŠEBEJ, Jiřina MEDALOVÁ, Peter ŠTACKO and Petr KLÁN. Near-Infrared Fluorescent 9-Phenylethynylpyronin Analogues for Bioimaging. The Journal of Organic Chemistry. American Chemical Society, 2014, vol. 79, No 8, p. 3374-3382. ISSN 0022-3263. Available from: https://dx.doi.org/10.1021/jo500140y.
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Basic information
Original name Near-Infrared Fluorescent 9-Phenylethynylpyronin Analogues for Bioimaging
Authors PASTIERIK, Tomáš (703 Slovakia, belonging to the institution), Peter ŠEBEJ (703 Slovakia, belonging to the institution), Jiřina MEDALOVÁ (203 Czech Republic, belonging to the institution), Peter ŠTACKO (703 Slovakia, belonging to the institution) and Petr KLÁN (203 Czech Republic, guarantor, belonging to the institution).
Edition The Journal of Organic Chemistry, American Chemical Society, 2014, 0022-3263.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10401 Organic chemistry
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 4.721
RIV identification code RIV/00216224:14310/14:00073597
Organization unit Faculty of Science
Doi http://dx.doi.org/10.1021/jo500140y
UT WoS 000334823800008
Keywords in English Rhodamine analogue; Bioimaging; Near infrared fluorescence
Tags AKR, rivok
Changed by Changed by: Mgr. Jiřina Medalová, Ph.D., učo 176525. Changed: 13/3/2018 11:13.
Abstract
The syntheses and biological applications of two novel fluorescent 9-phenylethynylpyronin analogues containing either carbon or silicon at the position 10 are reported. Both fluorescent probes exhibited a relatively strong fluorescence in methanol and phosphate buffer saline in the near-infrared region (705–738 nm) upon irradiation of either of their absorption maxima in the blue and red regions. The compounds showed high selectivity toward mitochondria in myeloma cells in vivo and allowed their visualization in a favored tissue-transparent window, which makes them promising NIR fluorescent tags for applications in bioimaging.
Links
EE2.3.30.0037, research and development projectName: Zaměstnáním nejlepších mladých vědců k rozvoji mezinárodní spolupráce
GA13-25775S, research and development projectName: Vývoj viditelným světlem aktivovatelných skupin a fluorescenčních značek pro chemii a biologii
Investor: Czech Science Foundation
LO1214, research and development projectName: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX)
Investor: Ministry of Education, Youth and Sports of the CR
MUNI/A/0975/2009, interní kód MUName: Podpora výzkumné činnosti studentů v oblasti fyziologie a imunologie živočichů. (Acronym: VYFIŽ)
Investor: Masaryk University, Category A
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