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@article{1181027,
author = {Amchová, Petra and Kučerová, Jana and Giugliano, Valentina and Babinská, Zuzana and Zanda, Mary T. and Scherma, Maria and Dušek, Ladislav and Fadda, Paola and Micale, Vincenzo and Šulcová, Alexandra and Fratta, Walter and Fattore, Liana},
article_location = {Lausanne},
article_number = {March},
doi = {http://dx.doi.org/10.3389/fphar.2014.00044},
keywords = {Cannabinoid; Depression; Dopamine; Drug dependence; Methamphetamine; Olfactory bulbectomy; Serotonin; WIN55212-2},
language = {eng},
issn = {1663-9812},
journal = {Frontiers in Pharmacology},
title = {Enhanced self-administration of the CB1 receptor agonist WIN55,212-2 in olfactory bulbectomized rats: evaluation of possible serotonergic and dopaminergic underlying mechanisms},
url = {http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00044/abstract},
volume = {5},
year = {2014}
}
TY - JOUR
ID - 1181027
AU - Amchová, Petra - Kučerová, Jana - Giugliano, Valentina - Babinská, Zuzana - Zanda, Mary T. - Scherma, Maria - Dušek, Ladislav - Fadda, Paola - Micale, Vincenzo - Šulcová, Alexandra - Fratta, Walter - Fattore, Liana
PY - 2014
TI - Enhanced self-administration of the CB1 receptor agonist WIN55,212-2 in olfactory bulbectomized rats: evaluation of possible serotonergic and dopaminergic underlying mechanisms
JF - Frontiers in Pharmacology
VL - 5
IS - March
SP - "44-1"-"44-15"
EP - "44-1"-"44-15"
PB - Frontiers Media SA
SN - 16639812
KW - Cannabinoid
KW - Depression
KW - Dopamine
KW - Drug dependence
KW - Methamphetamine
KW - Olfactory bulbectomy
KW - Serotonin
KW - WIN55212-2
UR - http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00044/abstract
L2 - http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00044/abstract
N2 - Depression has been associated with drug consumption, including heavy or problematic cannabis use. According to an animal model of depression and substance use disorder comorbidity, we combined the olfactory bulbectomy (OBX) model of depression with intravenous drug self-administration procedure to verify whether depressive-like rats displayed altered voluntary intake of the CB1 receptor agonist WIN55,212-2 (WIN, 12.5 mg/kg/infusion). To this aim, olfactory-bulbectomized (OBX) and sham-operated (SHAM) Lister Hooded rats were allowed to self-administer WIN by lever-pressing under a continuous [fixed ratio 1 (FR-1)] schedule of reinforcement in 2 h daily sessions. Data showed that both OBX and SHAM rats developed stable WIN intake; yet, responses in OBX were constantly higher than in SHAM rats soon after the first week of training. In addition, OBX rats took significantly longer to extinguish the drug-seeking behavior after vehicle substitution. Acute pre-treatment with serotonin 5HT1B receptor agonist, CGS-12066B (2.5-10 mg/kg), did not significantly modify WIN intake in OBX and SHAM Lister Hooded rats. Furthermore, acute pre-treatment with CGS-12066B (10 and 15 mg/kg) did not alter responses in parallel groups of OBX and SHAM Sprague Dawley rats self-administering methamphetamine under higher (FR-2) reinforcement schedule with nose-poking as operandum. Finally, dopamine levels in the nucleus accumbens (NAc) of OBX rats did not increase in response to a WIN challenge, as in SHAM rats, indicating a dopaminergic dysfunction in bulbectomized rats. Altogether, our findings suggest that a depressive-like state may alter cannabinoid CB1 receptor agonist-induced brain reward function and that a dopaminergic rather than a 5-HT1B mechanism is likely to underlie enhanced WIN self-administration in OBX rats.
ER -
AMCHOVÁ, Petra, Jana KUČEROVÁ, Valentina GIUGLIANO, Zuzana BABINSKÁ, Mary T. ZANDA, Maria SCHERMA, Ladislav DUŠEK, Paola FADDA, Vincenzo MICALE, Alexandra ŠULCOVÁ, Walter FRATTA and Liana FATTORE. Enhanced self-administration of the CB1 receptor agonist WIN55,212-2 in olfactory bulbectomized rats: evaluation of possible serotonergic and dopaminergic underlying mechanisms. \textit{Frontiers in Pharmacology}. Lausanne: Frontiers Media SA, 2014, vol.~5, March, p.~''44-1''-''44-15'', 15 pp. ISSN~1663-9812. Available from: https://dx.doi.org/10.3389/fphar.2014.00044.
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