The present and future disease burden of hepatitis C virus
(HCV) infection with today's treatment paradigm

RAZAVI, H., I. WAKED, C. SARRAZIN, R. P. MYERS, R. IDILMAN, F. CALINAS, W. VOGEL, M. C. Mendes CORREA, C. HÉZODE, P. LÁZARO, U. AKARCA, S. ALEMAN, I. BALIK, T. BERG, F. BIHL, M. BILODEAU, A. J. BLASCO, C. E. Brandão MELLO, P. BRUGGMANN, M. BUTI, J. L. CALLEJA, H. CHEINQUER, P. B. CHRISTENSEN, M. CLAUSEN, H. S. M. COELHO, M. E. CRAMP, G. J. DORE, W. DOSS, A. S. DUBERG, M. H. EL-SAYED, G. ERGÖR, G. ESMAT, K. FALCONER, J. FÉLIX, M. L. G. FERRAZ, P. R. FERREIRA, S. FRANKOVA, J. GARCÍA-SAMANIEGO, J. GERSTOFT, J. A. GIRIA, F. L. Jr. GONÇALES, E. GOWER, M. GSCHWANTLER, M. Guimarães PESSÔA, S. J. HINDMAN, H. HOFER, Petr HUSA, M. KÅBERG, K. D. E. KAITA, A. KAUTZ, S. KAYMAKOGLU, M. KRAJDEN, H. KRARUP, W. LALEMAN, D. LAVANCHY, R. T. MARINHO, P. MAROTTA, S. MAUSS, C. MORENO, K. MURPHY, F. NEGRO, V. NEMECEK, N. ÖRMECI, A. L. H. ØVREHUS, J. PARKES, K. PASINI, K. M. PELTEKIAN, A. RAMJI, N. REIS, S. K. ROBERTS, W. M. ROSENBERG, F. ROUDOT-THORAVAL, S. D. RYDER, R. SARMENTO-CASTRO, D. SEMELA, M. SHERMAN, G. E. SHIHA, W. SIEVERT, J. SPERL, P. STÄRKEL, R. E. STAUBER, A. J. THOMPSON, P. URBANEK, P. Van DAMME, I. van THIEL, H. Van VLIERBERGHE, D. VANDIJCK, H. WEDEMEYER, N. WEIS, J. WIEGAND, A. YOSRY, A. ZEKRY, M. CORNBERG, B. MÜLLHAUPT and C. ESTES. The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm. JOURNAL OF VIRAL HEPATITIS. HOBOKEN: WILEY-BLACKWELL, 2014, vol. 21, Supplement 1, p. 34-59. ISSN 1352-0504. Available from: https://dx.doi.org/10.1111/jvh.12248.

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@article{1182601,
   author = {Razavi, H. and Waked, I. and Sarrazin, C. and Myers, R. P. and Idilman, R. and Calinas, F. and Vogel, W. and Correa, M. C. Mendes and Hézode, C. and Lázaro, P. and Akarca, U. and Aleman, S. and Balik, I. and Berg, T. and Bihl, F. and Bilodeau, M. and Blasco, A. J. and Mello, C. E. Brandão and Bruggmann, P. and Buti, M. and Calleja, J. L. and Cheinquer, H. and Christensen, P. B. and Clausen, M. and Coelho, H. S. M. and Cramp, M. E. and Dore, G. J. and Doss, W. and Duberg, A. S. and ElandSayed, M. H. and Ergör, G. and Esmat, G. and Falconer, K. and Félix, J. and Ferraz, M. L. G. and Ferreira, P. R. and Frankova, S. and GarcíaandSamaniego, J. and Gerstoft, J. and Giria, J. A. and Gonçales, F. L. Jr. and Gower, E. and Gschwantler, M. and Pessôa, M. Guimarães and Hindman, S. J. and Hofer, H. and Husa, Petr and Kåberg, M. and Kaita, K. D. E. and Kautz, A. and Kaymakoglu, S. and Krajden, M. and Krarup, H. and Laleman, W. and Lavanchy, D. and Marinho, R. T. and Marotta, P. and Mauss, S. and Moreno, C. and Murphy, K. and Negro, F. and Nemecek, V. and Örmeci, N. and Øvrehus, A. L. H. and Parkes, J. and Pasini, K. and Peltekian, K. M. and Ramji, A. and Reis, N. and Roberts, S. K. and Rosenberg, W. M. and RoudotandThoraval, F. and Ryder, S. D. and SarmentoandCastro, R. and Semela, D. and Sherman, M. and Shiha, G. E. and Sievert, W. and Sperl, J. and Stärkel, P. and Stauber, R. E. and Thompson, A. J. and Urbanek, P. and Damme, P. Van and Thiel, I. van and Vlierberghe, H. Van and Vandijck, D. and Wedemeyer, H. and Weis, N. and Wiegand, J. and Yosry, A. and Zekry, A. and Cornberg, M. and Müllhaupt, B. and Estes, C.},
   article_location = {HOBOKEN},
   article_number = {Supplement 1},
   doi = {http://dx.doi.org/10.1111/jvh.12248},
   keywords = {HCV; diagnosis; treatment; hepatitis C; prevalence; epidemiology; disease burden; mortality; incidence},
   language = {eng},
   issn = {1352-0504},
   journal = {JOURNAL OF VIRAL HEPATITIS},
   title = {The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm},
   volume = {21},
   year = {2014}
}

TY  - JOUR
ID  - 1182601
AU  - Razavi, H. - Waked, I. - Sarrazin, C. - Myers, R. P. - Idilman, R. - Calinas, F. - Vogel, W. - Correa, M. C. Mendes - Hézode, C. - Lázaro, P. - Akarca, U. - Aleman, S. - Balik, I. - Berg, T. - Bihl, F. - Bilodeau, M. - Blasco, A. J. - Mello, C. E. Brandão - Bruggmann, P. - Buti, M. - Calleja, J. L. - Cheinquer, H. - Christensen, P. B. - Clausen, M. - Coelho, H. S. M. - Cramp, M. E. - Dore, G. J. - Doss, W. - Duberg, A. S. - El-Sayed, M. H. - Ergör, G. - Esmat, G. - Falconer, K. - Félix, J. - Ferraz, M. L. G. - Ferreira, P. R. - Frankova, S. - García-Samaniego, J. - Gerstoft, J. - Giria, J. A. - Gonçales, F. L. Jr. - Gower, E. - Gschwantler, M. - Pessôa, M. Guimarães - Hindman, S. J. - Hofer, H. - Husa, Petr - Kåberg, M. - Kaita, K. D. E. - Kautz, A. - Kaymakoglu, S. - Krajden, M. - Krarup, H. - Laleman, W. - Lavanchy, D. - Marinho, R. T. - Marotta, P. - Mauss, S. - Moreno, C. - Murphy, K. - Negro, F. - Nemecek, V. - Örmeci, N. - Øvrehus, A. L. H. - Parkes, J. - Pasini, K. - Peltekian, K. M. - Ramji, A. - Reis, N. - Roberts, S. K. - Rosenberg, W. M. - Roudot-Thoraval, F. - Ryder, S. D. - Sarmento-Castro, R. - Semela, D. - Sherman, M. - Shiha, G. E. - Sievert, W. - Sperl, J. - Stärkel, P. - Stauber, R. E. - Thompson, A. J. - Urbanek, P. - Damme, P. Van - Thiel, I. van - Vlierberghe, H. Van - Vandijck, D. - Wedemeyer, H. - Weis, N. - Wiegand, J. - Yosry, A. - Zekry, A. - Cornberg, M. - Müllhaupt, B. - Estes, C.
PY  - 2014
TI  - The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm
JF  - JOURNAL OF VIRAL HEPATITIS
VL  - 21
IS  - Supplement 1
SP  - 34-59
EP  - 34-59
PB  - WILEY-BLACKWELL
SN  - 13520504
KW  - HCV
KW  - diagnosis
KW  - treatment
KW  - hepatitis C
KW  - prevalence
KW  - epidemiology
KW  - disease burden
KW  - mortality
KW  - incidence
N2  - The disease burden of hepatitis C virus (HCV) is expected to increase as the infected population ages. A modelling approach was used to estimate the total number of viremic infections, diagnosed, treated and new infections in 2013. In addition, the model was used to estimate the change in the total number of HCV infections, the disease progression and mortality in 2013-2030. Finally, expert panel consensus was used to capture current treatment practices in each country. Using today's treatment paradigm, the total number of HCV infections is projected to decline or remain flat in all countries studied. However, in the same time period, the number of individuals with late-stage liver disease is projected to increase. This study concluded that the current treatment rate and efficacy are not sufficient to manage the disease burden of HCV. Thus, alternative strategies are required to keep the number of HCV individuals with advanced liver disease and liver-related deaths from increasing.
ER  -

Basic information
Original name	The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm
Authors	RAZAVI, H. (840 United States of America), I. WAKED (818 Egypt), C. SARRAZIN (276 Germany), R. P. MYERS (124 Canada), R. IDILMAN (792 Turkey), F. CALINAS (620 Portugal), W. VOGEL (40 Austria), M. C. Mendes CORREA (76 Brazil), C. HÉZODE (250 France), P. LÁZARO (724 Spain), U. AKARCA (792 Turkey), S. ALEMAN (752 Sweden), I. BALIK (792 Turkey), T. BERG (276 Germany), F. BIHL (756 Switzerland), M. BILODEAU (124 Canada), A. J. BLASCO (724 Spain), C. E. Brandão MELLO (76 Brazil), P. BRUGGMANN (756 Switzerland), M. BUTI (724 Spain), J. L. CALLEJA (724 Spain), H. CHEINQUER (76 Brazil), P. B. CHRISTENSEN (208 Denmark), M. CLAUSEN (208 Denmark), H. S. M. COELHO (76 Brazil), M. E. CRAMP (826 United Kingdom of Great Britain and Northern Ireland), G. J. DORE (36 Australia), W. DOSS (818 Egypt), A. S. DUBERG (752 Sweden), M. H. EL-SAYED (818 Egypt), G. ERGÖR (792 Turkey), G. ESMAT (818 Egypt), K. FALCONER (752 Sweden), J. FÉLIX (620 Portugal), M. L. G. FERRAZ (76 Brazil), P. R. FERREIRA (76 Brazil), S. FRANKOVA (203 Czech Republic), J. GARCÍA-SAMANIEGO (724 Spain), J. GERSTOFT (208 Denmark), J. A. GIRIA (620 Portugal), F. L. Jr. GONÇALES (76 Brazil), E. GOWER (840 United States of America), M. GSCHWANTLER (40 Austria), M. Guimarães PESSÔA (76 Brazil), S. J. HINDMAN (840 United States of America), H. HOFER (40 Austria), Petr HUSA (203 Czech Republic, guarantor, belonging to the institution), M. KÅBERG (752 Sweden), K. D. E. KAITA (124 Canada), A. KAUTZ (56 Belgium), S. KAYMAKOGLU (792 Turkey), M. KRAJDEN (124 Canada), H. KRARUP (208 Denmark), W. LALEMAN (56 Belgium), D. LAVANCHY (756 Switzerland), R. T. MARINHO (620 Portugal), P. MAROTTA (124 Canada), S. MAUSS (276 Germany), C. MORENO (56 Belgium), K. MURPHY (840 United States of America), F. NEGRO (756 Switzerland), V. NEMECEK (203 Czech Republic), N. ÖRMECI (792 Turkey), A. L. H. ØVREHUS (208 Denmark), J. PARKES (826 United Kingdom of Great Britain and Northern Ireland), K. PASINI (840 United States of America), K. M. PELTEKIAN (124 Canada), A. RAMJI (124 Canada), N. REIS (620 Portugal), S. K. ROBERTS (36 Australia), W. M. ROSENBERG (826 United Kingdom of Great Britain and Northern Ireland), F. ROUDOT-THORAVAL (250 France), S. D. RYDER (826 United Kingdom of Great Britain and Northern Ireland), R. SARMENTO-CASTRO (620 Portugal), D. SEMELA (756 Switzerland), M. SHERMAN (124 Canada), G. E. SHIHA (818 Egypt), W. SIEVERT (36 Australia), J. SPERL (203 Czech Republic), P. STÄRKEL (56 Belgium), R. E. STAUBER (40 Austria), A. J. THOMPSON (36 Australia), P. URBANEK (203 Czech Republic), P. Van DAMME (56 Belgium), I. van THIEL (276 Germany), H. Van VLIERBERGHE (56 Belgium), D. VANDIJCK (56 Belgium), H. WEDEMEYER (276 Germany), N. WEIS (208 Denmark), J. WIEGAND (792 Turkey), A. YOSRY (818 Egypt), A. ZEKRY (36 Australia), M. CORNBERG (276 Germany), B. MÜLLHAUPT (756 Switzerland) and C. ESTES (840 United States of America).
Edition	JOURNAL OF VIRAL HEPATITIS, HOBOKEN, WILEY-BLACKWELL, 2014, 1352-0504.

Other information
Original language	English
Type of outcome	Article in a journal
Field of Study	30300 3.3 Health sciences
Country of publisher	United States of America
Confidentiality degree	is not subject to a state or trade secret
Impact factor	Impact factor: 3.909
RIV identification code	RIV/00216224:14110/14:00075468
Organization unit	Faculty of Medicine
Doi	http://dx.doi.org/10.1111/jvh.12248
UT WoS	000333893200003
Keywords in English	HCV; diagnosis; treatment; hepatitis C; prevalence; epidemiology; disease burden; mortality; incidence
Tags	EL OK
Tags	International impact, Reviewed
Changed by	Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 13/5/2014 16:58.

Abstract

The disease burden of hepatitis C virus (HCV) is expected to increase as the infected population ages. A modelling approach was used to estimate the total number of viremic infections, diagnosed, treated and new infections in 2013. In addition, the model was used to estimate the change in the total number of HCV infections, the disease progression and mortality in 2013-2030. Finally, expert panel consensus was used to capture current treatment practices in each country. Using today's treatment paradigm, the total number of HCV infections is projected to decline or remain flat in all countries studied. However, in the same time period, the number of individuals with late-stage liver disease is projected to increase. This study concluded that the current treatment rate and efficacy are not sufficient to manage the disease burden of HCV. Thus, alternative strategies are required to keep the number of HCV individuals with advanced liver disease and liver-related deaths from increasing.

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The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment ...

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