NOVÁK, Jan, Peter KRUŽLIAK, Julie BIENERTOVÁ VAŠKŮ, Ondřej SLABÝ and Miroslav NOVÁK. MicroRNA-206: a Promising Theranostic Marker. THERANOSTICS. LAKE HAVEN: IVYSPRING INT PUBL, 2014, vol. 4, No 2, p. 119-133. ISSN 1838-7640. doi:10.7150/thno.7552.
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Basic information
Original name MicroRNA-206: a Promising Theranostic Marker
Authors NOVÁK, Jan (203 Czech Republic, guarantor, belonging to the institution), Peter KRUŽLIAK (203 Czech Republic), Julie BIENERTOVÁ VAŠKŮ (203 Czech Republic, belonging to the institution), Ondřej SLABÝ (203 Czech Republic, belonging to the institution) and Miroslav NOVÁK (203 Czech Republic).
Edition THERANOSTICS, LAKE HAVEN, IVYSPRING INT PUBL, 2014, 1838-7640.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30105 Physiology
Country of publisher Australia
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 8.022
RIV identification code RIV/00216224:14110/14:00075488
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.7150/thno.7552
UT WoS 000334663600001
Keywords in English microRNA-206; Theranostic Marker
Tags EL OK, podil
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 17. 12. 2014 13:14.
Abstract
MicroRNAs (miRs) are small non-coding RNAs that negatively regulate gene expression by binding to the 3 ' untranslated regions (3 ' UTR) of their target mRNAs. MiRs were shown to play pivotal roles in tissue development and function and are also involved in the pathogenesis of various diseases including cancer. MicroRNA-206, which belongs to the group of so-called "myomiRs", is one of the most studied miRs thus far. In addition to being involved in skeletal muscle development and pathology, it has also been established that it is involved in the pathogenesis of numerous diseases including heart failure, chronic obstructive pulmonary disease, Alzheimer's disease and various types of cancers. The aim of this review is to provide a complex overview of microRNA-206, including regulating its expression, a brief description of its known functions in skeletal muscle and a complex overview of its roles in the biology and pathology of other tissues, emphasizing its significant diagnostic and therapeutic potential.
Links
MUNI/A/0951/2012, interní kód MUName: Studium mechanismů vzniku vybraných kardiovaskulárních nemocí a poúrazových stavů (Acronym: SMEKAONUR)
Investor: Masaryk University, Category A
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