BIENERTOVÁ-VAŠKŮ, Julie, Ivo NEČESÁNEK, Jan NOVÁK, Jan VINKLÁREK and Filip ZLÁMAL. "Stress entropic load" as a transgenerational epigenetic response trigger. Medical Hypotheses. Edinburg: Churchill Livingstone, 2014, vol. 82, No 3, p. 271-274. ISSN 0306-9877. doi:10.1016/j.mehy.2013.12.008.
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Basic information
Original name "Stress entropic load" as a transgenerational epigenetic response trigger
Authors BIENERTOVÁ-VAŠKŮ, Julie (203 Czech Republic, guarantor, belonging to the institution), Ivo NEČESÁNEK (203 Czech Republic, belonging to the institution), Jan NOVÁK (203 Czech Republic, belonging to the institution), Jan VINKLÁREK (203 Czech Republic, belonging to the institution) and Filip ZLÁMAL (203 Czech Republic, belonging to the institution).
Edition Medical Hypotheses, Edinburg, Churchill Livingstone, 2014, 0306-9877.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30105 Physiology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.074
RIV identification code RIV/00216224:14110/14:00075489
Organization unit Faculty of Medicine
UT WoS 000333494100006
Tags EL OK, podil
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 13. 2. 2015 13:42.
Epigenetic changes are generally based on the switching of alternative functional or structural states and result in the adaptation of cellular expression patterns during proliferation, differentiation or plastic changes in the adult organism, whereas some epigenetic information can be passed on other generations while other is not. Hence, the principal question is: why is some information reset or resolved during the meiosis process and other is passed from one generation to another, or, in other words: what "adaptation trigger" level initiates transgenerationally transmitted epigenome change? Hereto, we propose a theory which states that stress, or, more specifically, the energy cost of an individual's adaptation to stress, represents a viable candidate for the transgenerational transmission trigger of a given acquired trait. It has been reported recently that the higher lifetime entropy generation of a unit's body mass, the higher the entropy stress level (which is a measure of energy released by a unit's organ mass) and the irreversibility within the organ, resulting in faster organ degradation and consequent health problems for the entire biological system. We therefore suggest a new term: "stress entropic load" will reflect the actual energetic cost of an individual's adaptation and may be used to estimate the pronbility of inducing transgenerational response once characterized or measured.
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