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@article{1182755,
author = {Blahová, Eva and Máchal, Jan and Máchal, Ladislav and Milaković, Irina and Hanuláková, Šárka},
article_location = {Athens},
article_number = {4},
doi = {http://dx.doi.org/10.3892/etm.2014.1522},
keywords = {pregnancy rate; sperm morphology; intracytoplasmic sperm injections; reproduction rate},
language = {eng},
issn = {1792-0981},
journal = {Experimental and Therapeutic Medicine},
title = {Eliminating the effect of pathomorphologically formed sperm on resulting gravidity using the intracytoplasmic sperm injection method},
url = {http://www.spandidos-publications.com/etm/7/4/1000},
volume = {7},
year = {2014}
}
TY - JOUR
ID - 1182755
AU - Blahová, Eva - Máchal, Jan - Máchal, Ladislav - Milaković, Irina - Hanuláková, Šárka
PY - 2014
TI - Eliminating the effect of pathomorphologically formed sperm on resulting gravidity using the intracytoplasmic sperm injection method
JF - Experimental and Therapeutic Medicine
VL - 7
IS - 4
SP - 1000-1004
EP - 1000-1004
PB - Spandidos Publications Ltd.
SN - 17920981
KW - pregnancy rate
KW - sperm morphology
KW - intracytoplasmic sperm injections
KW - reproduction rate
UR - http://www.spandidos-publications.com/etm/7/4/1000
N2 - The aim of the present study was to test whether it is possible to eliminate a high percentage of morphologically abnormal sperm in male ejaculate by assisted reproduction using the intracytoplasmic sperm injection (ICSI) method. Treatment success was evaluated by comparing fertilization, clinical pregnancy and reproduction rates between males with heavy teratospermia (<= 1% morphologically normal spermatozoa) and males with a higher percentage (>1%) of normal sperm. In total, 174 patients who had previously undergone 174 ICSI cycles (1 per each pair) were evaluated retrospectively. In the group of patients with heavily impaired sperm morphology (n=37), the percentage of normal spermatozoa was <= 1%. In the second group, males with >1% normal spermatozoa (n=137) were considered as patients with mildly impaired sperm morphology. The results of partner fertilization in these two groups were compared and a lower number of fertilized oocytes was identified in the patients with heavily impaired sperm morphology (P=0.038). However, neither the gravidity nor the take-home baby rates of the partners differed between the patients with mildly and heavily impaired sperm morphology. Trends opposite to that for fertilization were observed for gravidity and delivery [odds ratio (OR), 0.62; 95% confidence interval (CI), 0.29-1.30; OR, 0.55; 95% CI, 0.26-1.24, respectively]. This indicates that the lower number of fertilized oocytes was not associated with the overall outcome of fertilization and that patients with heavily impaired sperm morphology experience the same benefit from ICSI as patients with mildly impaired sperm morphology.
ER -
BLAHOVÁ, Eva, Jan MÁCHAL, Ladislav MÁCHAL, Irina MILAKOVI$\backslash$'C a Šárka HANULÁKOVÁ. Eliminating the effect of pathomorphologically formed sperm on resulting gravidity using the intracytoplasmic sperm injection method. \textit{Experimental and Therapeutic Medicine}. Athens: Spandidos Publications Ltd., 2014, roč.~7, č.~4, s.~1000-1004. ISSN~1792-0981. Dostupné z: https://dx.doi.org/10.3892/etm.2014.1522.
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