KOTOLOVÁ, Hana, Kateřina HORSKÁ and Jana KUČEROVÁ. Adipose Tissue Endocrine Regulations in Metabolic Syndrome and Appetite. In Julie Bienertová Vašků. Appetite: Regulation, Use of Stimulants and Cultural and Biological Influences. New York: Nova Science Publishers, 2014. p. 97-122, 26 pp. Human Anatomy and Physiology. ISBN 978-1-63117-243-4.
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Basic information
Original name Adipose Tissue Endocrine Regulations in Metabolic Syndrome and Appetite
Name in Czech Endokrinní regulace tukové tkáně u metabolického syndromu a chuti k jídlu
Authors KOTOLOVÁ, Hana (203 Czech Republic), Kateřina HORSKÁ (203 Czech Republic) and Jana KUČEROVÁ (203 Czech Republic, guarantor, belonging to the institution).
Edition New York, Appetite: Regulation, Use of Stimulants and Cultural and Biological Influences, p. 97-122, 26 pp. Human Anatomy and Physiology, 2014.
Publisher Nova Science Publishers
Other information
Original language English
Type of outcome Chapter(s) of a specialized book
Field of Study 30104 Pharmacology and pharmacy
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Publication form electronic version available online
RIV identification code RIV/00216224:14110/14:00075512
Organization unit Faculty of Medicine
ISBN 978-1-63117-243-4
Keywords (in Czech) metabolický syndrom; adipokiny; leptin; adiponektin; resistin; AFABP
Keywords in English metabolic syndrome; adipokines; leptin; adiponectin; resistin; AFABP
Tags EL OK
Tags International impact
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 13/7/2020 10:03.
Abstract
The current worldwide epidemic of metabolic syndrome represents an urgent challenge for new pharmacotherapy development. There is growing evidence of multiple metabolic dysregulations contributing to the development of the pathophysiological processes underlying metabolic syndrome. The adipose tissue metabolism and its endocrine activity is one of the key mechanisms believed to provide new targets for pharmacotherapy. The aim of this chapter is to provide a survey on metabolic syndrome pathophysiology, etiology and hypotheses of its development with special attention focused on insulin resistance, inflammatory processes and endocrine activity of the adipose tissue. Specific adipokines secreted by the body fat have multiple effects on the energy metabolism and can either support or suppress insulin signaling. Their pharmacological exploitation may lead to development of new treatments of insulin resistance and metabolic syndrome. Furthermore, possible common underlying processes between appetite regulation and metabolic syndrome pathophysiology are discussed.
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