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@inbook{1183181,
author = {Kotolová, Hana and Horská, Kateřina and Kučerová, Jana},
address = {New York},
booktitle = {Appetite: Regulation, Use of Stimulants and Cultural and Biological Influences},
editor = {Julie Bienertová Vašků},
keywords = {metabolic syndrome; adipokines; leptin; adiponectin; resistin; AFABP},
howpublished = {elektronická verze "online"},
language = {eng},
location = {New York},
isbn = {978-1-63117-243-4},
pages = {97-122},
publisher = {Nova Science Publishers},
title = {Adipose Tissue Endocrine Regulations in Metabolic Syndrome and Appetite},
year = {2014}
}
TY - CHAP
ID - 1183181
AU - Kotolová, Hana - Horská, Kateřina - Kučerová, Jana
PY - 2014
TI - Adipose Tissue Endocrine Regulations in Metabolic Syndrome and Appetite
VL - Human Anatomy and Physiology
PB - Nova Science Publishers
CY - New York
SN - 9781631172434
KW - metabolic syndrome
KW - adipokines
KW - leptin
KW - adiponectin
KW - resistin
KW - AFABP
N2 - The current worldwide epidemic of metabolic syndrome represents an urgent challenge for new pharmacotherapy development. There is growing evidence of multiple metabolic dysregulations contributing to the development of the pathophysiological processes underlying metabolic syndrome. The adipose tissue metabolism and its endocrine activity is one of the key mechanisms believed to provide new targets for pharmacotherapy. The aim of this chapter is to provide a survey on metabolic syndrome pathophysiology, etiology and hypotheses of its development with special attention focused on insulin resistance, inflammatory processes and endocrine activity of the adipose tissue. Specific adipokines secreted by the body fat have multiple effects on the energy metabolism and can either support or suppress insulin signaling. Their pharmacological exploitation may lead to development of new treatments of insulin resistance and metabolic syndrome. Furthermore, possible common underlying processes between appetite regulation and metabolic syndrome pathophysiology are discussed.
ER -
KOTOLOVÁ, Hana, Kateřina HORSKÁ and Jana KUČEROVÁ. Adipose Tissue Endocrine Regulations in Metabolic Syndrome and Appetite. In Julie Bienertová Vašků. \textit{Appetite: Regulation, Use of Stimulants and Cultural and Biological Influences}. New York: Nova Science Publishers. p.~97-122. Human Anatomy and Physiology. ISBN~978-1-63117-243-4. 2014.
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