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@article{1183299,
author = {Novák, Jan and Bienertová Vašků, Julie and Kára, Tomáš and Novák, Miroslav},
article_location = {New York},
article_number = {275867},
doi = {http://dx.doi.org/10.1155/2014/275867},
keywords = {microRNA; lipid metabolism; atherosclerosis; circulating microRNA},
language = {eng},
issn = {0962-9351},
journal = {Mediators of Inflammation},
title = {MicroRNAs Involved in the Lipid Metabolism and Their Possible Implications for Atherosclerosis Development and Treatment},
url = {http://www.hindawi.com/journals/mi/2014/275867/},
volume = {2014},
year = {2014}
}
TY - JOUR
ID - 1183299
AU - Novák, Jan - Bienertová Vašků, Julie - Kára, Tomáš - Novák, Miroslav
PY - 2014
TI - MicroRNAs Involved in the Lipid Metabolism and Their Possible Implications for Atherosclerosis Development and Treatment
JF - Mediators of Inflammation
VL - 2014
IS - 275867
SP - 1-14
EP - 1-14
PB - Hindawi Publishing Corporation
SN - 09629351
KW - microRNA
KW - lipid metabolism
KW - atherosclerosis
KW - circulating microRNA
UR - http://www.hindawi.com/journals/mi/2014/275867/
N2 - Hyperlipidemia is a well-accepted risk factor in the development of atherosclerosis. MicroRNAs (miRNAs), a novel class of posttranscriptional regulators of gene expression, are involved in a variety of biological and pathological processes, including the regulation of the lipid metabolism and atherosclerosis. As our knowledge of miRNAs expands, a new class of "circulating miRNAs" has recently been described. It includes miRNAs which may be found in various bodily fluids packaged in microvesicles/exosomes, or bound to specific transporting proteins. High-density lipoprotein (HDL) particles have been identified as one such carrier. As this class of miRNAs likely plays a role in intercellular communication, it may also contribute to the atherosclerosis development and progression. This review aims to provide a comprehensive explanation of the roles of distinct miRNAs involved in the regulation of the lipid metabolism. These microRNAs seem to be promising therapeutic agents, as documented in rodents and African green monkeys. The second part of the review focuses on circulating miRNAs and their involvement in the atherosclerosis, especially as their levels have been described as altered in patients with dyslipidemia/hyperlipidemia. Special emphasis is placed on miRNAs transported in a complex with HDL particles and on those which may be considered potential atherosclerosis biomarkers.
ER -
NOVÁK, Jan, Julie BIENERTOVÁ VAŠKŮ, Tomáš KÁRA and Miroslav NOVÁK. MicroRNAs Involved in the Lipid Metabolism and Their Possible Implications for Atherosclerosis Development and Treatment. \textit{Mediators of Inflammation}. New York: Hindawi Publishing Corporation, 2014, vol.~2014, No~275867, p.~1-14. ISSN~0962-9351. Available from: https://dx.doi.org/10.1155/2014/275867.
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